HOME >> BIOLOGY >> NEWS
Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process

at the germ line signal inhibits DAF-16.

Next, they deducted that the germ cell signal doesn't act on DAF-2. When they deleted germ cells in animals in which the DAF-2 gene was defective, the nematodes lived twice as long as the already long-lived animals missing DAF-2, which is four times as long as normal. The researchers reasoned that if the germ cells worked through DAF-2, their absence would not have mattered, because the mutants lack the DAF-2 receptor anyway.

"The idea is you get even more DAF-16 activity if you kill both the germ cells and disrupt DAF-2," said Kenyon. "This shows that the germ cells operate independently of DAF-2. If either DAF-2 or germ cells are defective, DAF-16 levels rise and the animals live longer. If both are missing, DAF-16 levels rise even more, and the animals live even longer."

The bigger challenge was teasing out the role and mode of operation of the somatic gonads. The researchers knew that the reproductive tissue surrounding the germ cells had some role, because when they killed both the germ cells and the surrounding tissue the roundworms lived a normal lifespan. This was a very important finding, because it showed that just having progeny did not shorten the lifespan of the animal. Thus, contrary to the predictions of some theorists, there was no tradeoff between having progeny and living longer.

Instead, it indicated that that somatic gonad also produced signals that regulated lifespan. If the somatic gonads had no effect, the animals would have lived a longer than normal lifespan, given that the germ cell signal's lifespan-repressing action would have been missing.

The researchers could not tease out the unique impact of the somatic gonads, however, because killing the somatic gonads required killing the germ cells, as well, since the germ cells are embedded in the somatic tissue and cannot develop in their absence. The investigators' solution was to try to reveal the somatic gonad's unique
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
26-May-1999


Page: 1 2 3 4 5

Related biology news :

1. University Of Kentucky Professor Teaches First Reproductive Laboratory Science Class In The United States
2. Largest Generation Of Adolescents Faces Reproductive Health Risks
3. Epilepsy: Signals brake in brain impaired
4. Cell Suicide Prevented By Survival Signals
5. Toxic Protein That Interferes With Brain Signals May Trigger Onset Of Alzheimers Disease
6. Maternal Anxiety May Affect Fetal Development
7. Duke Study Finds More Genes May Be Affected By Toxic Cadmium
8. Chopping And Cooking Affect Garlics Anti-Cancer Activity
9. Gene Influences How Lifestyle Affects Blood Cholesterol
10. Wake Forest Physicians Demonstrate How Gene-Diet Interaction Affects Cholesterol Absorption
11. The Best Molecular Snapshot Yet Of Cells Affected By Alzheimers Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... International research firm Parks Associates announced today that Tom ... 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and ...
(Date:10/9/2017)... SAN DIEGO , Oct. 9, 2017 /PRNewswire/ ... a biological mechanism by which its ProCell stem ... of critical limb ischemia.  The Company, demonstrated that ... the amount of limbs saved as compared to ... of the molecule HGF resulted in reduction of ...
(Date:10/9/2017)... Antonio, Texas (PRWEB) , ... ... ... new study published on October 5, 2017, in the medical journal, Epilepsia, ... equivalence with the gold standard, video EEG, in detecting generalized tonic-clonic seizures ...
(Date:10/6/2017)... Boston, Mass. (PRWEB) , ... October 06, 2017 ... ... spotlight female entrepreneurship within the healthcare and technology sector at their fourth annual ... six panels featuring 30 inspiring speakers and the ELEVATE pitch competition showcasing early ...
Breaking Biology Technology:
Cached News: