HOME >> BIOLOGY >> NEWS
Research Findings Suggest Potent, Broad-Spectrum Antiviral Activity For Vertex's Investigational IMPDH Inhibitor VX-497

The investigational drug VX-497 may have potent, broad-spectrum antiviral activity, according to laboratory results presented by scientists from Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) at the 12th International Conference on Antiviral Research held this week in Jerusalem, Israel. VX-497's activity against viruses in cell culture was compared to that of the antiviral compound ribavirin, both alone and in combination with interferonalpha. Vertex is evaluating VX-497 in Phase II clinical trials for HCV infection and as an immunosuppressant for psoriasis.

VX-497 is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a human enzyme that is essential for the de novo production of guanosine nucleotides (for example, GTP)-one of the building blocks of RNA and DNA. Inhibition of IMPDH may be an effective strategy for blocking the rapid proliferation (growth) of certain cell types which uniquely depend upon this de novo pathway--such as B and T lymphocytes--as well as blocking viral replication, which is often more dependent on the de novo pathway than on the alternative "salvage" pathway of nucleotide biosynthesis used by most human cells.

In one study comparing the activity of VX-497 versus ribavirin against selected DNA and RNA viruses in vitro, VX-497 was found to be 15-to 186-fold more potent than ribavirin against hepatitis B virus, human cytomegalovirus, respiratory syncytial virus, herpes simplex virus type 1, parainfluenza-3 virus, and Venezuelan equine encephalitis virus. Preliminary data suggests VX-497 may be more potent than ribavirin against bovine viral diarrhea virus and as potent as ribavirin against dengue virus.

In another study, using cells infected with encephalomyocarditis virus (EMCV), VX-497 was shown to have 15-to 40-fold more potent antiviral activity in combination with interferon-alpha, when compared to a combination of ribavirin plus interferon-alpha. Ribavirin is marketed in the
'"/>

Contact: Michele Karpf
karpf@vpharm.com
617-577-6259
Vertex Pharmaceuticals
25-Mar-1999


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
9. Research suggests new avenue for stopping, preventing colon cancer
10. Researchers develop fast track way to discover how cells are regulated
11. Research on carbohydrate metabolism receives historical recognition

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/27/2018)... ... November 27, 2018 , ... Veni Vici, or Anthony, is a competitive Hunter-Jumper owned ... knee. At the time, he was fourteen years old and Lisa was told he ... enough to be a trail horse. Devasted, Lisa sought the expert opinion of veterinarian ...
(Date:11/20/2018)... ... 2018 , ... SF Bay Cosmetic Body Sculpting announces the ... non-invasive buttock lift procedure, with no injections necessary! Utilizing HIFEM® technology to induce ... buttocks to provide a safe and completely non-invasive alternative to popular yet controversal ...
(Date:11/16/2018)... ... November 16, 2018 , ... Bergeson & Campbell, ... and it will engage listeners in intelligent, insightful conversation about everything related to ... B&C’s talented team of lawyers, scientists, and consultants will keep listeners abreast of ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... ... November 13, 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has begun ... Dr. Leadbeater, of Kahala Pet Hospital on Oahu, is a skilled ... traveling to the island of Kauai on an almost weekly basis to perform surgery ...
(Date:11/13/2018)... , ... November 13, 2018 , ... ... Aqua® Research Water Life Science® in Grants Pass, Oregon believes in the power ... Bio-Logic Aqua® Research Water Life Science® sponsors the Power of Water® on talk ...
(Date:11/7/2018)... , ... November 07, 2018 , ... ... been leading a campaign to increase awareness of the adult tissue stem cell ... the month of November, the company is intensifying this effort with new educational ...
(Date:11/5/2018)... , ... November 05, 2018 , ... ... live educational support for healthcare professionals through its website, http://www.glycomark.com , as ... a live chat and video option via the website in November from 9 ...
Breaking Biology Technology:
Cached News: