WASHINGTON, D.C. April 1 -- For the first time, researchers have found that a particularly lethal form of brain cancer tramples through healthy tissue with the help of a tumor-specific molecule. They hope that methods that can debilitate the molecule, brain-enriched hyaluronan binding protein (BEHAB), will slow the progression of the disease.
"The experiments show that BEHAB appears to be a strong, central factor in the movement of brain cancer cells into healthy brain tissue," says neurobiology professor and lead author of the study, Susan Hockfield, PhD, of Yale University School of Medicine. "The work raises new therapeutic possibilities for the brain cancer tumors known as gliomas, which are often fatal."
Hockfield's study, funded by the National Institutes of Health, is published in the April 1 issue of The Journal of Neuroscience.
"The work is exciting because it advances our basic understanding of how glioma cells invade healthy brain tissue and provides a new animal model that can be used to evaluate future therapies," says Lois Lampson, PhD, an expert on brain tumor biology and an associate neurology professor at Brigham and Women's Hospital and Harvard Medical School. "The research opens new paths for both basic understanding and pre-clinical research."
Each year, approximately 20,000 Americans find out they have a glioma. More than half die within 18 months because the tumors often outsmart conventional treatments, such as surgery.
Gliomas arise from brain support cells called glia. The cells grow furiously until they form a mass known as a tumor. "Gliomas are exceptionally difficult to treat because their cells have an unusual ability to travel long distances through normal brain tissue and set up new tumors," says Hockfield.
"One approach to controlling the cancer would be to block the glioma cells'
ability to travel, without harming healthy cells." BEHAB, also known as
Contact: Leah Ariniello
Society for Neuroscience