HOME >> BIOLOGY >> NEWS
Research collaboration identifies gene essential to puberty

One of the great mysteries of human biology is what controls the timing and onset of puberty. By studying patients who fail to undergo puberty and using information made available by the Human Genome Project, American and British research teams have collaborated to identify a gene that appears to be a key regulator of puberty in humans and in mice.

In a report published in the October 23 New England Journal of Medicine, scientists from Massachusetts General Hospital (MGH) and from Paradigm Therapeutics and the University of Cambridge in the U.K. describe mutations in the gene for a protein called GPR54 that prevent both humans and mice from undergoing normal puberty and sexual maturation. This gene makes a receptor protein that probably is a key trigger of the hormonal cascade required for mammalian reproduction. The discovery could lead to new infertility treatments or contraceptive options, among other applications.

"It looks like we have found a key genetic gatekeeper of puberty in mice and men," says William Crowley Jr., MD, chief of the MGH Reproductive Endocrine Unit and director of the Harvardwide Reproductive Endocrine Sciences Center, one of three co-senior authors of the NEJM report. "Most other genes involved in reproductive control are species-specific, but this gene shows robust activity across two very different mammalian species."

The MGH effort led by Stephanie Seminara, MD, of the Reproductive Endocrine Unit began as a search for genes that cause idiopathic hypogonadotropic hypogonadism (IHH), a relatively unusual disorder in which puberty does not occur at the usual age. Normal puberty begins when the hypothalamus, a structure deep within the brain, begins to secrete gonadotropin-releasing hormone (GnRH). In response to this secretion, the pituitary gland releases hormones called gonadotropins, which in turn stimulate the ovaries or testes to start releasing estrogen and testosterone. Individuals with IHH fail to
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
22-Oct-2003


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
9. Research suggests new avenue for stopping, preventing colon cancer
10. Researchers develop fast track way to discover how cells are regulated
11. Research on carbohydrate metabolism receives historical recognition

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/28/2020)... ... February 26, 2020 , ... ... its patent-pending Rebound PRP™ and Rebound PRF® devices are now available to ... generation of regenerative medical devices, that will provide the most affordable, easiest ...
(Date:2/26/2020)... ... February 25, 2020 , ... Renowned eye surgical practice ... first practices in Texas to offer the FDA-approved, post-surgical, corrective Light Adjustable Lens (LAL) ... been placed with excellent results. Dell Laser Consultants is also currently involved in the ...
(Date:2/13/2020)... ... February 13, 2020 , ... ... Assessment Report: The Laboratory Analytical & Life Science Instrumentation Industry. The report will ... gold standard of market intelligence for the $70 billion laboratory market for analytical ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... ... January 24, 2020 , ... ... RedySmart™ mass flow meters and controllers ideal for BioPharm OEMS. ... upgrade to antiquated rotameters. These thermal instruments employ high-precision MEMS (Micro-Electro Mechanical Systems) ...
(Date:1/22/2020)... Wis. (PRWEB) , ... January 21, 2020 , ... ... the hiring of Darrell Taylor as Southern Midwest Region Industrial and Institutional (I&I) ... the SporActiv™ product line. , Darrell brings over 30 years of ...
(Date:1/10/2020)... ... January 09, 2020 , ... A new report ... for the vendor qualification process, a critical element of clinical trial set up ... of the vendor qualification process creates delays in initiation in 7% of clinical ...
(Date:1/8/2020)... ... January 08, 2020 , ... Anomet Products ... properties for use in harsh environments inside or outside of the human body. ... metals or alloys to achieve specific properties such as corrosion-resistance, biocompatibility, or operation ...
Breaking Biology Technology:
Cached News: