HOME >> BIOLOGY >> NEWS
Research collaboration identifies gene essential to puberty

One of the great mysteries of human biology is what controls the timing and onset of puberty. By studying patients who fail to undergo puberty and using information made available by the Human Genome Project, American and British research teams have collaborated to identify a gene that appears to be a key regulator of puberty in humans and in mice.

In a report published in the October 23 New England Journal of Medicine, scientists from Massachusetts General Hospital (MGH) and from Paradigm Therapeutics and the University of Cambridge in the U.K. describe mutations in the gene for a protein called GPR54 that prevent both humans and mice from undergoing normal puberty and sexual maturation. This gene makes a receptor protein that probably is a key trigger of the hormonal cascade required for mammalian reproduction. The discovery could lead to new infertility treatments or contraceptive options, among other applications.

"It looks like we have found a key genetic gatekeeper of puberty in mice and men," says William Crowley Jr., MD, chief of the MGH Reproductive Endocrine Unit and director of the Harvardwide Reproductive Endocrine Sciences Center, one of three co-senior authors of the NEJM report. "Most other genes involved in reproductive control are species-specific, but this gene shows robust activity across two very different mammalian species."

The MGH effort led by Stephanie Seminara, MD, of the Reproductive Endocrine Unit began as a search for genes that cause idiopathic hypogonadotropic hypogonadism (IHH), a relatively unusual disorder in which puberty does not occur at the usual age. Normal puberty begins when the hypothalamus, a structure deep within the brain, begins to secrete gonadotropin-releasing hormone (GnRH). In response to this secretion, the pituitary gland releases hormones called gonadotropins, which in turn stimulate the ovaries or testes to start releasing estrogen and testosterone. Individuals with IHH fail to
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
22-Oct-2003


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
9. Research suggests new avenue for stopping, preventing colon cancer
10. Researchers develop fast track way to discover how cells are regulated
11. Research on carbohydrate metabolism receives historical recognition

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... Join Jonathan Riek, PhD, VP, Musculoskeletal ... Tuesday, September 10, 2019 at 1pm EDT to learn about two common imaging methods ... , NAFLD is the most common diffuse liver disease, with a worldwide prevalence of ...
(Date:8/14/2019)... TORONTO (PRWEB) , ... August 13, 2019 , ... ... Cancer Medicine Team, Division of Molecular Pathology, Institute of Cancer Research (ICR) in ... (5pm BST/UK) to learn about the process of biomarker and companion diagnostic development ...
(Date:8/6/2019)... ... August 06, 2019 , ... ... modeling system that could have far-reaching implications for personalized medicine, especially when seeking ... (PLSR), is able to predict which stem cell donors and manipulation methods might ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... ... July 16, 2019 , ... ... agreement for the development and manufacturing of Zolgensma® (onasemnogene abeparvovec-xioi), an AveXis ... AveXis, a Novartis company, will have dedicated manufacturing space at the new, ...
(Date:7/9/2019)... FLORENCE, Ky. (PRWEB) , ... July 08, 2019 ... ... Sensors” Award winner. The company’s SmartLight Indicator was recognized as the 2019 Innovative ... the sensors industry forward. The prestigious awards were during Sensors Expo & ...
(Date:6/18/2019)... ... 18, 2019 , ... Personalized Stem Cells, Inc (“PSC”), a human ... FDA for use of a person’s own adipose-derived stem cells to treat their osteoarthritis. ... knee. This IND is the first of several planned clinical trials which will ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... will add 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed ... DeepDyve’s continually expanding library of more than 20 million articles, sourced from more ...
Breaking Biology Technology:
Cached News: