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Research finds tumor preventive qualities, damage reversal, in green tea

PHOENIX Drinking green tea may do more than just thwart a head cold, according to research presented today at the American Association for Cancer Research Second Annual International Conference on Frontiers in Cancer Prevention Research. Green tea already is believed to help lower cholesterol and prevent heart disease, fight bacteria and dental cavities, and possibly aid weight loss. New studies are now suggesting the various potential anti-cancer benefits of the age-old beverage.

"Laboratory studies have suggested that green tea consumption may produce many health benefits, including the prevention of cancer, but the beneficial effects in humans are not clearly known," said CS Yang, Ph.D., of Rutgers University, N.J.

"Research is now showing how this novel chemopreventive agent might work at the molecular level and in the human population," he added.

Inhibition of VEGF Expression and Tumor Cell Growth in Breast Cancer Cells by Novel Synthetic Analogs of the Green Tea Catechin, Epigallocatecin-3-gallate (EGCG) (Abstract 1560)

EGCG (epigallocatchin-3-gallate) is the most abundant and active chemopreventive agent in green tea, and has been associated with reduced risk of breast, pancreatic, colon, esophageal and lung cancers in humans. However, EGCG has a low oral bioavailability, meaning that to sustain effective levels for biological activity, individuals would need to drink at least seven to eight cups of tea a day, or ingest large amounts of green tea polyphenol extract. Researchers from SRI International in Menlo Park, Calif., have successfully synthesized several EGCG analogs that inhibit the in vitro (in an artificial environment) growth of tumor cell lines with potencies equal to or greater than EGCG itself.

The investigators developed a chemical synthesis of cis racemic EGCG that allows them to modify the A-, B- and D-rings of EGCG independently of each other. Using this method, they created several different an
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Contact: Aimee Frank
amf@spectrumscience.com
202-955-6222
American Association for Cancer Research
28-Oct-2003


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