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Research highlights from Pacific Northwest National Laboratory

Device sounds off on cracks

A cracked bolt may not faze Tim "The Tool Man" Taylor as he does home improvements, but it can debilitate an industrial or nuclear plant if undetected. A new inspection device developed at the Department of Energy's Pacific Northwest National Laboratory detects cracks in bolts more easily and less expensively than alternatives.

Pacific Northwest's device relies on ultrasonic electronics to retrieve more accurate readings by limiting background noise. Also, the device allows fasteners to be inspected while in place, thereby reducing inspection time and allowing periodic monitoring. Inspectors have a greater opportunity to interpret the data and make repair decisions with a complementary computer tool that gives a visual representation of the fastener and any fractures or degradation.

'Doctored up' cotton for improved healing

Innovative methods of altering cotton gauze to enhance the healing of chronic wounds are being developed by researchers at Pacific Northwest, the U.S. Department of Agriculture and Virginia Commonwealth University's Medical College of Virginia Hospitals. Approximately two million Americans, including diabetics and those confined to beds and wheelchairs, suffer from non-healing wounds.

Studies show a link between chronic wounds and elevated levels of the enzyme elastase, which is known to degrade proteins such as fibronectin required for tissue repair. This association has prompted research into methods to alter cotton to remove elastase without sacrificing the material's valuable properties, such as absorbency and air permeability.

In one approach, researchers synthesized a peptide "recognition site" for elastase on the cotton surface that absorbs the degradative enzyme away from the wound.

The modified dressings are scheduled to enter clinical trials at Medical College of Virginia Hospitals in spring 2000.

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Contact: Media Relations
barbara.sorenson@pnl.gov
509-375-3776
DOE/Pacific Northwest National Laboratory
18-Jan-2000


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