HOME >> BIOLOGY >> NEWS
Research reveals genetic makeup of salmonella responsible for food poisoning

St. Louis, Oct.24, 2001 Scientists at Washington University School of Medicine in St. Louis have mapped and sequenced the genome for a bacterium that is a leading cause of food poisoning worldwide: Salmonella typhimurium. The sequence has yielded new potential targets for future drug and vaccine development and gives possible insights into how the bacterium causes disease. The work is published in the Oct. 25 issue of the journal Nature.

Typhimurium infects humans, cattle, chickens, and other warm-blooded animals. The rod-shaped bacterium is important in bacterial-genetics research, and disabled strains are used in live vaccines and to deliver anti-cancer drugs to tumor cells. It also causes a typhoid-fever-like illness in mice that is used as a model for studies related to human typhoid fever. Typhimurium is thought to be responsible for an estimated 1.4 million cases of food poisoning in the United States each year, and about a 1,000 deaths. The intestinal illness usually resolves on its own, but sometimes the bacterium enters the bloodstream causing an infection that may be fatal if not treated with antibiotics. But that is becoming increasingly difficult.

Antibiotic resistance is a growing problem in Typhimurium, says principal investigator Richard Wilson, Ph.D., associate professor of genetics and co-director of the Genome Sequencing Center at the School of Medicine. Ideally, we hope this work will identify possible new drug targets and reduce the threat of ever-more resistant strains of the bacterium.

In addition to researchers at Washington University, the Typhimurium team included investigators at the Sidney Kimmel Cancer Center in San Diego; the University of Calgary in Alberta, Canada; and Pennsylvania State University.

The investigators identified 4,595 suspected genes in the Typhimurium genome, many of which were previously unknown. They include 156 probable membrane proteins that are potential drug or vaccine targets.

The
'"/>

Contact: Darrell E. Ward
wardd@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
24-Oct-2001


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
9. Research suggests new avenue for stopping, preventing colon cancer
10. Researchers develop fast track way to discover how cells are regulated
11. Research on carbohydrate metabolism receives historical recognition

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... , ... August 05, 2020 , ... Regenative Labs has ... new innovations, CoreText™ and ProText™, making them the first Wharton’s jelly allografts to be ... a syringe. The company’s solutions are the first Wharton’s jelly allograft product to be ...
(Date:7/18/2020)... ... 2020 , ... A study has been published in the ... noise control device to attenuate typical noises in a simulated neonatal intensive care ... sounds from patient monitors, ventilators and other bedside devices that would affect the ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , ... biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology ... Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has introduced new ... for use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical ... requirements, performance, and cost criteria; especially where solid wire is limited. Typical configurations ...
(Date:7/31/2020)... FRANCISCO (PRWEB) , ... July ... ... provider of cloud-based software for the life sciences industry, today announced the ... presentation platform designed specifically for Medical Science Liaisons (MSLs) and other field ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... the early detection and prevention of high-burden diseases, and Centric Consulting, a business ... healthcare organizations to utilize existing data in order to identify and prioritize patients ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research using the ... pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over ... been using the zebrafish model to investigate the causes of leukaemia and its ...
Breaking Biology Technology:
Cached News: