HOME >> BIOLOGY >> NEWS
Research suggests new avenue for stopping, preventing colon cancer

NASHVILLE, Tenn. Researchers at the Vanderbilt-Ingram Cancer Center (VICC) have provided the first evidence that blocking a cellular receptor can inhibit the development of pre-cancerous colon polyps in mice.

The research suggests a new avenue for stopping or preventing colon cancer, which kills more than 50,000 Americans each year, said the paper's senior author, Raymond N. DuBois, M.D., Ph.D., Hortense B. Ingram Professor of Molecular Oncology and the VICC's associate director for Cancer Prevention and Control.

The receptor, called PPARdelta, plays an important role in development, wound healing and fat metabolism. In the current issue of the journal Cancer Cell, the scientists reported that they could inhibit polyp development in mice by "knocking out" the PPARdelta gene. PPAR stands for peroxisome proliferator-activated receptor, a family of three "transcription factors" that serve as on-off switches for a wide variety of genes.

DuBois is internationally known for his pioneering studies linking the development of colorectal cancer to the cyclooxygenase-2 (COX-2) enzyme. COX-2 is a major target for drugs that relieve the pain and inflammation of arthritis, but COX-2 gene expression is also elevated in a variety of malignancies including colorectal tumors.

COX-2 generates several potent, hormone-like substances called prostaglandins that play a role in a wide variety of physiological functions. One of them, prostaglandin E2 (PGE2), has been specifically linked to the development of colon polyps. The current study tested the effect of PGE2 in mice with the mutation that made them susceptible to polyps. Administration of the prostaglandin dramatically increased the number of intestinal polyps.

The animals were then crossed with mice without the PPARdelta gene. This generated animals with the propensity to develop colon polyps but lacking PPARdelta. When PGE2 was given to these mice, "we didn't seen any increase in polyps," DuBois said
'"/>

Contact: Cynthia Floyd Manley
cynthia.manley@vanderbilt.edu
615-936-5711
Vanderbilt University Medical Center
20-Sep-2004


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
9. Researchers develop fast track way to discover how cells are regulated
10. Research on carbohydrate metabolism receives historical recognition
11. Researchers identify distinctive signature for metastatic prostate cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2019)... ... 19, 2019 , ... BioInformatics Inc., part of Science and ... of the life science research and advisory firm. As the leader of the ... market research and media revenue operations in the company. Mark’s responsibilities will span ...
(Date:2/19/2019)... , ... February 18, 2019 ... ... global provider of advanced delivery technologies and development solutions for drugs, biologics ... & Gamble Company’s (P&G) highest external business partner recognition, the External Business ...
(Date:2/19/2019)... ... 18, 2019 , ... The Idea, Emma came home from her first day of elementary school ... must be an app out there to make her homework a little more fun. Unable ... Words. , The idea is simple enough: help children learn the vocabulary they see in ...
Breaking Biology News(10 mins):
(Date:2/19/2019)... POWAY, Calif. (PRWEB) , ... February 19, 2019 , ... ... with clinical, regulatory and manufacturing experience. In October 2018, VetStem authorized the formation ... has licensed to PSC its stem cell patents, data, and FDA filings to launch ...
(Date:2/16/2019)... ... February 14, 2019 , ... DaVinci is a comprehensive ... also provides the flexibility for users to bring their own data and tools ... workbench to conduct quick analytics on near-real-time data to gain timely insights on ...
(Date:2/14/2019)... ... February 14, 2019 , ... ... leak testing systems for the pharmaceutical, biotechnology and food industries, formally announced today ... Brian Mulhall has been named Chief Executive Officer and will oversee ...
(Date:2/12/2019)... (PRWEB) , ... February 12, 2019 , ... ... in dermatology, has finalized a deal to extend their use of Medrio, the ... trials, through 2023. The CRO has been a regular Medrio customer for over ...
Breaking Biology Technology:
Cached News: