Research suggests new avenue for stopping, preventing colon cancer


"Our results identify PPARdelta as a critical downstream mediator in PGE2-stimulated promotion of colorectal tumor growth," the researchers concluded.

A drug that blocks PPARdelta has been developed in France, and the Vanderbilt researchers hope to test it in mice to see if it has the same effect as knocking out the gene. "We've been carefully examining drugs which inhibit COX-2," DuBois explained. "Now we can really focus on key components of the downstream pathway."

The research could lead to more specific and safer -- ways to prevent colorectal cancer. In addition to generating PGE2, the COX-2 enzyme produces another prostaglandin that blocks clot formation and dilates blood vessels. Long-term, high-dose use of the COX-2 inhibitor Vioxx has been linked to high blood pressure and an increased risk of serious heart problems in some patients.

Last month, researchers at the Salk Institute in La Jolla reported that activating PPARdelta in mice stimulated changes in muscle fibers that enabled the animals to run "marathons" and eat a high-fat diet without gaining weight. A drug that turns on PPARdelta is being tested in patients with fat metabolism disorders.

However, when the drug was given to a strain of mice with a genetic mutation that makes them susceptible to developing pre-cancerous intestinal polyps, both the number and size of polyps increased significantly, DuBois and his colleagues reported last February in Nature Medicine. The same mutation is found in 80 percent of patients with colorectal cancer.

The findings suggest that drugs that activate PPARdelta "may encourage abnormal cell growth in certain populations at risk for colorectal cancer," DuBois cautioned.

DuBois credited Sudhansu K. Dey, Ph.D., who directs the division of Reproductive and Developmental Biology at Vanderbilt, with maintaining the PPARdelta "knockout" mouse colony that made the study possible. Dey, DuBois and their colleagues previously have demo

Contact: Cynthia Floyd Manley
Vanderbilt University Medical Center

Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
9. Researchers develop fast track way to discover how cells are regulated
10. Research on carbohydrate metabolism receives historical recognition
11. Researchers identify distinctive signature for metastatic prostate cancer

Post Your Comments:

(Date:7/22/2020)... ... July 21, 2020 , ... USDM ... technology and compliance, announces a new solution to manage regulated workloads on Microsoft ... of their technology stack complies with FDA and global regulations. USDM's new managed ...
(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced ... will share insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional ... Advantage will be live on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, ...
(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, a global leader ... Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga prefecture of Japan. ... in Kakegawa, the new 60,000-square-foot facility will provide customers with flexible clinical supply ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... ... True Terpenes , the leading platform for terpene innovation, research and development, ... medical potential of terpenes and the potential entourage effect , where the benefits ... on expanding the recently launched line of effects-based terpenes - Terpology by Dr. ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... validation engineering firm, is making available for free its new white paper ... concurrent transport simulation testing into today’s biologics licensing application (BLA). In response, ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... today announced the launch of its new tagline, “BUILDING FOR LIFE.” The adoption ... industry and around the globe, requiring fast track capacity to provide patients with ...
Breaking Biology Technology:
Cached News: