Research yields new insights into molecular control of addiction

In research employing fruit flies, scientists at the University of Arizona have provided new insights into how molecules may control addiction, memory formation, and brain plasticity. Their research has provided the first evidence that the molecule AP1, which helps to regulate changes in the manufacture of certain proteins in brain cells, also is required for long-term changes in the function of synapses (the connections between brain cells).

The study, funded by the National Institute on Drug Abuse (NIDA), is published in the April 25, 2002 issue of Nature. NIDA Acting Director Dr. Glen R. Hanson says that understanding addiction at the molecular level will help in the search for new pharmacologic agents to treat or interrupt the biological processes that result in addiction.

It has been known that long-term behavioral changes, such as drug addiction, are associated with changes in the manufacture of certain proteins in brain cells. Animal studies have identified a few key molecules such as CREB and AP1 that regulate these changes. For example, a variant form of AP1, called deltaFosB, is produced in the brain after multiple exposures to cocaine and controls long-term sensitization to the drug.

The prevailing view is that production of AP1 is activated by CREB. Once produced, AP1 helps CREB direct the manufacture of a subset of proteins required to modify the function of brain cells that control behavior.

Lead investigator Dr. Mani Ramaswami says that although it had been believed that AP1 helps generate changes in synapses, direct evidence has been lacking until now.

The Arizona researchers analyzed the role of AP1 in synaptic change. A surprise finding, says Dr. Ramaswami, is that the synaptic changes controlled by AP1 are more extensive than those controlled by CREB, and more closely resemble synaptic changes induced by real experience. Also unexpected was the observation that the activity of AP1 was increas

Contact: Michelle Muth Person
NIH/National Institute on Drug Abuse

Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
9. Research suggests new avenue for stopping, preventing colon cancer
10. Researchers develop fast track way to discover how cells are regulated
11. Research on carbohydrate metabolism receives historical recognition

Post Your Comments:

(Date:8/27/2019)... ... August 27, 2019 , ... Ambry ... to improve genetic testing guidelines. In the largest cohort study of its kind, ... more at-risk patients. , Clinicians use guidelines to inform decisions about which ...
(Date:8/21/2019)... ... August 21, 2019 , ... AbSci, a revolutionary synthetic biology ... biomanufacturing of complex protein therapeutics, today announced the appointment of Fred Larimore, PhD, ... Dr. Larimore brings more than 30 years of experience in biopharmaceutical manufacturing and ...
(Date:8/15/2019)... (PRWEB) , ... August 15, 2019 , ... ... passed. Now what? As serialization mandates become increasingly complex, and aggregation becomes fully ... current serialization software is the best long-term solution. , Until now, most regulations?including ...
Breaking Biology News(10 mins):
(Date:9/8/2019)... , ... September 05, 2019 , ... ... Blaine Fitzgerald, former Vice President of Finance for Shopify, has been named Chief ... and healthcare venture capitalist Joel Finlayson as strategic advisors. Additionally, Spartan has hired ...
(Date:8/29/2019)... ... August 28, 2019 , ... ... DuPont™ Danisco® ingredient solutions to attendees at the International Baking Industry Expo, September ... baking challenges from optimizing production efficiency to cost and waste reduction and from ...
(Date:8/25/2019)... ... August 23, 2019 , ... ... 1 best-selling status for the scientific research book “Impact of Biofield Treatment on ... and perfume industry as Patchouli. , The book garnered No. 1 status ...
(Date:8/14/2019)... ... August 13, 2019 , ... INDIGO ... toxicology testing solutions, announced the appointment of Mark McLoughlin to the Company’s Board ... , Mark McLoughlin will lend his healthcare expertise and extensive background in laboratory ...
Breaking Biology Technology:
Cached News: