HOME >> BIOLOGY >> NEWS
Researcher Awarded Patent For System To Fight Multiple Diseases

St. Louis, April 13, 1999 -- After waiting for nearly 18 years, Roy Curtiss III, Ph.D., George William and Irene Koechig Freiberg Professor of Biology at Washington University in St. Louis, was granted a United States patent for his genetically engineered bacterial antigen delivery system March 30, 1999.

The patent, "Recombinant Avirulent Bacterial Antigen Delivery System," is number 5, 888, 799. It was originally filed on October 22, 1981. Washington University and the University of Alabama, Birmingham (UAB) will share patent income equally from any vaccine marketed to combat any bacterial, viral, fungal or parasitic disease using Curtiss' concept.

Curtiss developed the system while on the faculty of UAB in the late 1970s and early 1980s and at Washington University since 1983. The patent covers composition, manufacture and use of live attenuated, or weakened, derivatives of disease-causing bacteria genetically engineered to express foreign antigens, or proteins, in a vaccine; the vaccine then homes in on lymph tissue in an individual to induce immune responses against the foreign antigens.

Curtiss conceived the initial ideas for the patent in the late 1970s and early 1980s when he was using gene cloning to express protein antigens from streptococcal bacteria in E. coli. One purpose of these studies was to develop a recombinant vaccine that would induce anti-streptococcal immunity in an individual after taking an oral vaccine.

In 1981, when Curtiss filed the patent application, introducing genes from one pathogen into another was not possible because such gene cloning was prohibited by the National Institutes of Health (NIH) Guidelines for Recombinant DNA Research. Curtiss helped draft the guidelines in the 1970s as an original member of the NIH Recombinant DNA Advisory Committee. Although international patents on this technology first were granted in 1989, the U.S. Patent and Trademark Office had ru
'"/>

Contact: Tony Fitzpatrick
314-935-5272
Washington University in St. Louis
13-Apr-1999


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced the first in a ... the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles ... on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of ...
(Date:7/1/2020)... ... July 01, 2020 , ... ... had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in ... Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot facility will provide ...
(Date:6/25/2020)... MANSFIELD, Mass. (PRWEB) , ... June 24, 2020 ... ... provider of cloud-based enterprise software and software-driven clinical data services that accelerate drug ... trials for low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader ... tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at a time ... track capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical ...
(Date:7/31/2020)... ... July 29, 2020 , ... The ... centers in 16 countries, has reached its 20th anniversary of worldwide use. Introduced ... use at top universities including University of Pennsylvania, University of Michigan, University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... in the early detection and prevention of high-burden diseases, and Centric Consulting, a ... and healthcare organizations to utilize existing data in order to identify and prioritize ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its Chief ... clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as an ...
Breaking Biology Technology:
Cached News: