HOME >> BIOLOGY >> NEWS
Researcher Awarded Patent For System To Fight Multiple Diseases

St. Louis, April 13, 1999 -- After waiting for nearly 18 years, Roy Curtiss III, Ph.D., George William and Irene Koechig Freiberg Professor of Biology at Washington University in St. Louis, was granted a United States patent for his genetically engineered bacterial antigen delivery system March 30, 1999.

The patent, "Recombinant Avirulent Bacterial Antigen Delivery System," is number 5, 888, 799. It was originally filed on October 22, 1981. Washington University and the University of Alabama, Birmingham (UAB) will share patent income equally from any vaccine marketed to combat any bacterial, viral, fungal or parasitic disease using Curtiss' concept.

Curtiss developed the system while on the faculty of UAB in the late 1970s and early 1980s and at Washington University since 1983. The patent covers composition, manufacture and use of live attenuated, or weakened, derivatives of disease-causing bacteria genetically engineered to express foreign antigens, or proteins, in a vaccine; the vaccine then homes in on lymph tissue in an individual to induce immune responses against the foreign antigens.

Curtiss conceived the initial ideas for the patent in the late 1970s and early 1980s when he was using gene cloning to express protein antigens from streptococcal bacteria in E. coli. One purpose of these studies was to develop a recombinant vaccine that would induce anti-streptococcal immunity in an individual after taking an oral vaccine.

In 1981, when Curtiss filed the patent application, introducing genes from one pathogen into another was not possible because such gene cloning was prohibited by the National Institutes of Health (NIH) Guidelines for Recombinant DNA Research. Curtiss helped draft the guidelines in the 1970s as an original member of the NIH Recombinant DNA Advisory Committee. Although international patents on this technology first were granted in 1989, the U.S. Patent and Trademark Office had ru
'"/>

Contact: Tony Fitzpatrick
314-935-5272
Washington University in St. Louis
13-Apr-1999


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... 05, 2019 , ... Keck Graduate Institute (KGI) President Sheldon Schuster has announced ... (SPHS). , “Dean Zdanowicz is highly regarded as an innovative leader who prioritizes student ... a great choice to build on the success of the KGI School of Pharmacy ...
(Date:8/4/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... free, so be sure to register today to save your place! Participate in the ... our upcoming webinars: , CLINICAL OPERATIONS , August 27 – Friend or Foe? An ...
(Date:8/1/2019)... ... August 01, 2019 , ... John R. Freeman, CPA, ... MD, PhD, founder and president of BioLabs, which provides premier co-working spaces for life ... to strengthen our ability to forecast and manage growth,” says Fruehauf. “BioLabs has expanded ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... July 08, 2019 , ... ... company’s SmartLight Indicator was recognized as the 2019 Innovative Product of the Year ... The prestigious awards were during Sensors Expo & Conference 2019, held ...
(Date:6/18/2019)... ... June 18, 2019 , ... Personalized Stem Cells, Inc (“PSC”), a ... the FDA for use of a person’s own adipose-derived stem cells to treat their ... the knee. This IND is the first of several planned clinical trials which ...
(Date:6/11/2019)... ... June 10, 2019 , ... DeepDyve ... its scientific journals to DeepDyve’s rental service for peer-reviewed journals. , IOPP’s ... of more than 20 million articles, sourced from more than 15,000 journals. , ...
(Date:6/6/2019)... ... June 05, 2019 , ... WCCT Global, Inc ... device industries, announced today that they will be receiving 3 awards at the 2019 ... WCCT received 2 awards in the categories of overall Quality and Compatibility (Access to ...
Breaking Biology Technology:
Cached News: