HOME >> BIOLOGY >> NEWS
Researcher explores tumors' survival strategy

Dr. Kouros Motamed is studying endothelial cells where they live, in the complex environment that provides, not only support and structure, but regulation and direction.

As he studies these cells that line blood vessels, this vascular biologist at the Medical College of Georgia focuses on the proteins and growth factors that regulate their normal processes, including proliferation, differentiation, migration and death.

He wants to better understand how these cells interact with their environment because there are still many unanswered questions.

But he also wants to know because tumors sometimes commandeer these cells' ability to grow new blood vessels that bring life-sustaining nutrients and oxygen. "For most tumors to become any larger than 2 to 3 millimeters (a small fraction of an inch) in diameter, they have to recruit blood vessels," said Dr. Motamed.

This new vessel growth, called angiogenesis, can be beneficial. An injury can throw an angiogenic switch, activating a previously quiet endothelial cell. "As a result of activation, the endothelial cell loses its contact with the matrix (the milieu cells live in), elongates and invades the surrounding, stromal tissue," Dr. Motamed said. The cell then begins to proliferate, forming the lumen through which blood will eventually flow, and recruits supporting cell types and matrix components to form a new, functional vascular bed that is believed to accelerate wound healing.

The fact that many tumors also activate angiogenesis to survive has helped make it a hot topic in science. Dr. Motamed, who came to MCG in September from The Hope Heart Institute in Seattle, has his eye on the role of basic fibroblast growth factor in promoting angiogenesis and a protein called SPARC, which seems to have multiple roles in cancer and new blood vessel formation.

"SPARC is a protein most abundant during tissue remodeling and repair," said Dr. Motamed. The protein has many functions inclu
'"/>

Contact: Toni Baker
tbaker@mail.mcg.edu
706-721-4421
Medical College of Georgia
20-Feb-2003


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/9/2016)... 9, 2016 Paris Police ... video security solution to ensure the safety of people and ... during the major tournament Teleste, an international technology ... services, announced today that its video security solution will be ... back up public safety across the country. The system roll-out ...
(Date:6/2/2016)... June 2, 2016 The Department of ... awarded the 44 million US Dollar project, for the ... Plates including Personalization, Enrolment, and IT Infrastructure , ... the production and implementation of Identity Management Solutions. Numerous renowned ... Decatur was selected for the most ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" ... by its major shareholders, Clean Technology Fund I, LP ... States based venture capital funds which together ... (on a fully diluted, as converted basis), that they ... their entire equity holdings in Biorem to TUS Holdings ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the ... today the Clinical Reach Virtual Patient Encounter CONSULT module which enables both ... physician and clinical trial team. , Using the CONSULT module, patients and physicians can ...
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... , June 24, 2016 Epic ... sensitively detects cancers susceptible to PARP inhibitors by ... tumor cells (CTCs). The new test has already ... therapeutics in multiple cancer types. Over ... DNA damage response pathways, including PARP, ATM, ATR, ...
Breaking Biology Technology:
Cached News: