HOME >> BIOLOGY >> NEWS
Researcher issues caution on live virus vaccines

VALHALLA, N.Y., June 18, 2004--A New York Medical College microbiologist warns that live virus vaccines to prevent infectious diseases like West Nile virus and yellow fever could have dire consequences. Should one of the vaccine flaviviruses recombine with a wild-type virus, a new microbe with potentially undesirable properties could result, according to Stephen J. Seligman, M.D., research professor of microbiology and immunology.

His paper, "Live flavivirus vaccines: reasons for caution" appears as a rapid review article in the June 19, 2004, issue of the journal Lancet. Co-author is Ernest A. Gould, Ph.D., of CEH-Oxford in the UK.

Flaviviruses, which can recombine within species and may recombine between species, also include dengue, Japanese encephalitis and tick-borne encephalitis. They cause substantial sickness and death each year. Although live-virus vaccines offer great promise in terms of cost and efficacy, their use should be approved by an international authority due to safety concerns, the authors write.

The article lists five main lessons learned from other live virus vaccines:

  • reversion of vaccine strains to increased virulence;
  • development of disease in individuals with compromised immune systems;
  • birth defects, particularly if the vaccine is given in the first trimester;
  • spread of vaccine strains to unvaccinated persons and;
  • the discovery of new, previously undetermined complications.


    '"/>



  • Contact: Donna E. Moriarty
    donna_moriarty@nymc.edu
    914-594-4536
    New York Medical College
    18-Jun-2004


    Page: 1

    Related biology news :

    1. Researchers determine genetic cause of Timothy syndrome
    2. Researchers find color sensitive atomic switch in bacteria
    3. Researchers identify protein promoting vascular tumor growth
    4. Researchers devise potent new tools to curb ivory poaching
    5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
    6. Researchers ID chlorophyll-regulating gene
    7. Researchers develop fast track way to discover how cells are regulated
    8. Researchers identify distinctive signature for metastatic prostate cancer
    9. Researchers report new gene test for isolated cleft lip and palate
    10. Researchers discover why mutant gene causes colon cancer
    11. Researchers identify the genomes controlling elements

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:8/15/2019)... ... August 15, 2019 , ... Make ... staff of routine tasks. That was the message at the world's largest gathering ... Information. The American Association for Clinical Chemistry (AACC) Annual Scientific Meeting was held ...
    (Date:8/14/2019)... ... August 14, 2019 , ... Join Jonathan Riek, PhD, VP, ... on Tuesday, September 10, 2019 at 1pm EDT to learn about two common imaging ... , NAFLD is the most common diffuse liver disease, with a worldwide prevalence ...
    (Date:8/14/2019)... ... August 13, 2019 , ... Join Anguraj Sadanandam, PhD, Team ... Cancer Research (ICR) in a live webinar on Wednesday, September 4, ... and companion diagnostic development including machine learning approaches in different gastrointestinal cancers and ...
    Breaking Biology News(10 mins):
    (Date:7/9/2019)... ... July 08, 2019 , ... Balluff has ... was recognized as the 2019 Innovative Product of the Year which highlights cutting-edge ... were during Sensors Expo & Conference 2019, held this week in ...
    (Date:6/26/2019)... ... June 26, 2019 , ... Alice Branton today released research results from preclinical ... Magnesium Gluconate, which can prove to be beneficial for treating Hypomagnesemia. , The preclinical ... change in crystallite size , Over 142% increase in particle size , ...
    (Date:6/18/2019)... (PRWEB) , ... June 18, 2019 , ... Personalized ... Investigational New Drug (IND) application to the FDA for use of a person’s own ... as a treatment of osteoarthritis in the knee. This IND is the first ...
    (Date:6/11/2019)... , ... June 10, 2019 , ... ... its distribution network with the appointment of Biofeedback Tech Ltd as ... systems are an essential part of many therapeutic treatments and clinical assessment protocols ...
    Breaking Biology Technology:
    Cached News: