HOME >> BIOLOGY >> NEWS
Researchers Demonstrate That COX-2 Inhibits Angiogenisis In Tumor Cells

Aspirin's preventive effects on colon cancer may result from its influence on the development of blood vessels needed for tumor growth, a Vanderbilt Cancer Center researcher reports in the Friday, May 29, issue of the journal Cell.

The work was done jointly by Dr. Raymond N. DuBois, Mina Cobb Wallace Professor of Gastroenterology and Cancer Prevention and director of the division of Gastroenterology, and colleagues at the Osaka University School of Medicine in Japan. The researchers demonstrated two ways in which aspirin can inhibit angiogenesis, an important component in the development and spread of cancer.

"What we found is that NSAIDs can work in two ways -- by inhibiting the enzyme cyclooxygenase-2 (COX-2) in the tumor cells, which then prevents production of factors that prompt angiogenesis, and by inhibiting cyclooxygenase-1 (COX-1) in endothelial cells, which form the blood vessels that grow into the tumor," DuBois said.

The research builds on earlier work by DuBois and his colleagues that suggested aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) help prevent colon cancer by inhibiting COX-2, which they found to be elevated in colon cancer cells.

However, this new research suggests that COX-1 -- and the ability of aspirin and NSAIDs to target it as well -- may also be involved. These studies were carried out in an in vitro model of angiogenesis involving a chamber with colon cancer cells on the bottom and endothelial cells on the top, separated by a porous collagen membrane.

In a series of experiments, the researchers first compared colon cancer cells that overexpress COX-2 to control cells. They found that the COX-2-positive colon carcinoma cells produced angiogenic factors that, in turn, stimulated migration of the endothelial cells across the collagen gel. These COX-2-positive colon cancer cells also prompted the endothelial cells to begin to form tube-like structu
'"/>

Contact: Matt Scanlan
matt.scanlan@mcmail.vanderbilt.edu
(615) 322-4747
Vanderbilt University Medical Center
29-May-1998


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... Market with the addition of its newest module, US Hemostats & Sealants. , ... thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in ...
(Date:10/12/2017)... San Diego, CA (PRWEB) , ... ... ... BioInformatics (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform ... eliminating all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its ... 2018 in San Francisco, CA. The Summit brings together current and former FDA office ... directors and government officials from around the world to address key issues in device ...
Breaking Biology Technology:
Cached News: