HOME >> BIOLOGY >> NEWS
Researchers Demonstrate That COX-2 Inhibits Angiogenisis In Tumor Cells

Aspirin's preventive effects on colon cancer may result from its influence on the development of blood vessels needed for tumor growth, a Vanderbilt Cancer Center researcher reports in the Friday, May 29, issue of the journal Cell.

The work was done jointly by Dr. Raymond N. DuBois, Mina Cobb Wallace Professor of Gastroenterology and Cancer Prevention and director of the division of Gastroenterology, and colleagues at the Osaka University School of Medicine in Japan. The researchers demonstrated two ways in which aspirin can inhibit angiogenesis, an important component in the development and spread of cancer.

"What we found is that NSAIDs can work in two ways -- by inhibiting the enzyme cyclooxygenase-2 (COX-2) in the tumor cells, which then prevents production of factors that prompt angiogenesis, and by inhibiting cyclooxygenase-1 (COX-1) in endothelial cells, which form the blood vessels that grow into the tumor," DuBois said.

The research builds on earlier work by DuBois and his colleagues that suggested aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) help prevent colon cancer by inhibiting COX-2, which they found to be elevated in colon cancer cells.

However, this new research suggests that COX-1 -- and the ability of aspirin and NSAIDs to target it as well -- may also be involved. These studies were carried out in an in vitro model of angiogenesis involving a chamber with colon cancer cells on the bottom and endothelial cells on the top, separated by a porous collagen membrane.

In a series of experiments, the researchers first compared colon cancer cells that overexpress COX-2 to control cells. They found that the COX-2-positive colon carcinoma cells produced angiogenic factors that, in turn, stimulated migration of the endothelial cells across the collagen gel. These COX-2-positive colon cancer cells also prompted the endothelial cells to begin to form tube-like structu
'"/>

Contact: Matt Scanlan
matt.scanlan@mcmail.vanderbilt.edu
(615) 322-4747
Vanderbilt University Medical Center
29-May-1998


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... At its national board meeting ... I. Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced Space ... membership in ARCS Alumni Hall of Fame . ASTER Labs is a ...
(Date:10/11/2017)... ... 11, 2017 , ... Personal eye wash is a basic first aid supply for any work ... which eye do you rinse first if a dangerous substance enters both eyes? It’s one ... with its unique dual eye piece. , “Whether its dirt and debris, or an ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... will be hosting a Webinar titled, “Pathology is going digital. Is your lab ... digital pathology adoption best practices and how Proscia improves lab economics and realizes ...
(Date:10/11/2017)... the Netherlands and LAGUNA HILLS, Calif. ... The Institute of Cancer Research, London ... use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients ... trial known as MUK nine . The University of ... trial, which is partly funded by Myeloma UK, and ICR ...
Breaking Biology Technology:
Cached News: