HOME >> BIOLOGY >> NEWS
Researchers Develop First Way To Immunize Against A Deadly Bacterium

Laboratory researchers have developed a new way to cripple a virulent class of microbes that have become increasingly resistant to antibiotics and continue to kill hundreds of thousands of hospital patients every year. The discovery, based on experiments with laboratory mice, provides immunization against the Pseudomonas aeruginosa bacterium, suggesting a fresh alternative to antibiotics in the fight against the microbes responsible for most hospital-acquired pneumonia deaths. The bacteria kill half the hospital patients they infect.

The new finding led by scientists at the University of California San Francisco and the Medical College of Wisconsin is reported in the April issue of Nature Medicine. A commentary on the research and its significance appears in the same issue.

Nationally, more than two billion dollars a year are spent combating hospital pneumonia, a condition most often contracted by patients already under intensive care.

The Pseudomonas species targeted in the research is also responsible for the untreatable lung inflammations which devastate the lives of half a million people with cystic fibrosis. In addition, it belongs to the same group of gram-negative bacteria as E. coli, Salmonella, and the microbe responsible for plague, all of which may be candidates for the same immunization strategy developed by the scientific team.

"All these species utilize the same combination of proteins to deliver deadly toxins to host cells," says Jeanine Wiener-Kronish, MD, professor of anesthesiology and medicine UC San Francisco and one of the senior authors on the Nature Medicine paper. "We have developed an antibody against one of these proteins and shown that it blocks Pseudomonas from injecting toxins into lung cells. This antibody may well provide immunization against these other bacteria species too."

Senior author on the Nature Medicine paper is Dara W. Frank, PhD, professor of microbiology and molecular genetics at the Medical Coll
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
30-Mar-1999


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... August 06, 2020 , ... ... in the prestigious National STEM Scholar Program, a unique professional development program that ... project support for middle school science teachers nationwide. , Created in partnership between ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... therapeutics product portfolio with a near term focus on Type 2 diabetes and ... commercialization experience across multiple therapeutic areas and classes. As Chief Commercial Officer, Justin ...
(Date:7/10/2020)... ... 08, 2020 , ... Overcoming Comparability Issues in Regenerative Medicines ... Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy , ... way to complete one? Will the study comply with all FDA requirements? Understanding ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... , ... August 11, 2020 , ... ... year to expand the Facioscapulohumeral Muscular Dystrophy Clinical Trial Research Network ... and 2022. The network is a consortium of academic research centers in the ...
(Date:8/3/2020)... ... 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company ... Known as MediVet Biologics since its formation in 2016, the company is relaunching ... Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... SOMERSET, N.J (PRWEB) , ... July 29, 2020 ... ... editing company, and Catalent, the leading global provider of advanced delivery technologies, development, ... products, today announced that they have entered into a strategic partnership whereby Catalent ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
Breaking Biology Technology:
Cached News: