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Researchers Develop First Way To Immunize Against A Deadly Bacterium

orts at control through antibiotics, she says. The bacteria also cause sepsis, or infection of the blood, by passing from the lungs into the bloodstream, and the scientists hope that sepsis too may be controlled through antibody therapy.

The research group is now working with InterMune Pharmaceutical, Inc. to develop an antibody therapy and a vaccine for use in clinical trials with patients. The scientists are also seeking to better understand how the bacterial type III secretory system works, expecting that further refinements in the immunization strategy might be possible.

"We're still in the development stages, but we think that studying PcrV may well reveal significant information about the process of intoxication by type III systems," said Dara Frank of the Medical College of Wisconsin.

Collaborating in the research and on the paper with Sawa, Frank and Wiener-Kronish were Maria Ohara, MD, and Kiyoyasu Kurahashi MD, both Fellows in anesthesiology and Michael Gropper, MD, PhD, assistant professor of anesthesiology, all at UCSF, and Timothy L. Yahr, PhD, a postdoctoral scientist at Dartmouth Medical School.

The research was funded by the National Institutes of Health and the Cystic Fibrosis Foundation.


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Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
30-Mar-1999


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