Researchers Discover Existing Drugs May Prevent Enlarged Hearts

DALLAS -- April 17, 1998 -- Using two drugs already available, researchers at UT Southwestern Medical Center at Dallas may have found a cure for a condition that puts 5 million Americans at risk for sudden death -- an enlarged heart, or cardiac hypertrophy.

In groundbreaking research Dr. Eric Olson, chairman of molecular biology and oncology, and his colleagues discovered a molecular pathway that leads to heart enlargement and have found a way to block that pathway using an immunosuppressant drug already approved by the Food and Drug Administration, although not for that condition. Their study, published in the April 17 issue of Cell, was done in mice whose progression from cardiac hypertrophy to heart failure to death mirrored humans'.

"Cardiac hypertrophy is the response of the heart to all sorts of damage, like hypertension or heart attacks or endocrine disorders or mutations. What the heart does is try to compensate for that damage by increasing its size to achieve greater cardiac output," said Olson.

Initially this is beneficial, but ultimately the heart may enlarge too much, causing congestive heart failure that can lead to sudden death. Half of cardiac hypertrophy patients die from the condition.

Olson and his research team showed that cardiac hypertrophy is controlled by a single protein, calcineurin, which acts as a gatekeeper to the cells nucleus, the control room where specific molecules regulate gene function. When stimulated by a sustained increase in the cells calcium level, calcineurin activates its target protein, NFAT3, which then enters the nucleus and turns on the genes that cause heart enlargement.

The researchers genetically engineered two strains of mice to test their hypotheses. One strain continually expressed activated calcineurin in heart muscle cells, which allowed activated NFAT3 to enter the nucleus and start the hyper

Contact: Heather Stieglitz
(214) 648-3404
UT Southwestern Medical Center

Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:8/5/2020)... PENSACOLA, Fla. (PRWEB) , ... August 05, 2020 , ... ... to cover two new innovations, CoreText™ and ProText™, making them the first Wharton’s jelly ... a defect using a syringe. The company’s solutions are the first Wharton’s jelly allograft ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead ... near term focus on Type 2 diabetes and associated comorbidities. , Justin brings ... areas and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
(Date:7/18/2020)... ... 2020 , ... Commercial launch readiness is a critical stage in a product ... or vaccine, the global economic downturn will only increase price pressures overall for the ... capturing full value from every product launch is critical. However, history shows that only ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted ... will cover the history of eSource, the reasons it did not take off as ... to site source, the industry is moving towards capturing data electronically for clinical trials ...
(Date:7/22/2020)... , ... July 22, 2020 , ... Join experts from ... Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar on ... regulating body in China for drugs and medical devices. Specifically, for medical devices, the ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... in the early detection and prevention of high-burden diseases, and Centric Consulting, a ... and healthcare organizations to utilize existing data in order to identify and prioritize ...
(Date:7/10/2020)... BALTIMORE (PRWEB) , ... July ... ... Baltimore biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has ... This broader license allows PathSensors to move into the point-of-care diagnostic market, ...
Breaking Biology Technology:
Cached News: