HOME >> BIOLOGY >> NEWS
Researchers Discover How Ulcer Bug Becomes Antibiotic-Resistant

St. Louis, April 13 -- Scientists in Halifax, Nova Scotia, and St. Louis, Mo., have discovered why the bacterium Helicobacter pylori, which causes peptic ulcer disease, is sensitive to metronidazole, a critical component of the leading H. pylori therapy. They also have determined how the bacterium becomes resistant to this drug. H. pylori infects more than half the world's people and is a major early risk factor for stomach cancer.

The researchers' findings also raise concern about a possible link between the drug and stomach cancer in people infected with H. pylori. "The real danger lurks when a person takes metronidazole without the complete complement of drugs that eradicate this bacterium," says Paul S. Hoffman, Ph.D., professor of microbiology and immunology and medicine at Dalhousie University Medical School in Halifax. "When metronidazole is taken alone, it can be activated by one of the bacterium's enzymes to produce hydroxylamine, a mutagen and cancer-causing chemical."

The collaborators describe their findings in the April 14 issue of Molecular Microbiology. Hoffman's graduate student, Avery Goodman, is lead author of the paper.

Metronidazole -- a generic drug sold as Flagyl, MetroGel and Protostat -- is prescribed for dental abscesses, certain vaginal infections and conditions where anaerobic bacteria or protozoan parasites are suspected. It also is the key component in combination therapies for peptic ulcer disease. But between 10 percent and 30 percent of H. pylori strains in the United States and Western Europe are metronidazole-resistant. In developing countries, the proportion may be as high as 80 percent. This resistance is the most common reason for treatment failure, renewal of infection and recurrence of peptic ulcers and other stomach lesions.

The researchers discovered that metronidazole resistance results from mutation in a gene called rdxA. This gene codes for one of the nitro
'"/>

Contact: Linda Sage
sage@medicine.WUSTL.edu
314-432-8566
Washington University School of Medicine
15-Apr-1998


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2017)... the thousands of attendees at this year,s International Consumer Electronics Show (CES), ... measurement devices and services, will be featuring its new line of ULTRA ... special CES Exhibit Suite , the new upper arm and wrist ... WellnessConnected product platform.  Continue Reading ... ...
(Date:12/22/2016)... YORK , December 22, 2016 ... provider of secure solutions for the e-Government, Public Safety, HealthCare, and ... subsidiary of SuperCom, has been selected to implement and deploy a ... in Northern California , further expanding its presence ... ...
(Date:12/16/2016)...   IdentyTechSolutions America LLC , a leading ... and a cutting-edge manufacturer of software and hardware ... seamless, integrated solutions that comprise IDT biometric readers ... provide IdentyTech,s customers with combined physical identification and ... and theft. "We are proud to ...
Breaking Biology News(10 mins):
(Date:1/14/2017)... , Jan. 13, 2017  The Alliance for ... in response to FDA final guidance on ... its continued leadership in emphasizing the importance of distinct ... keenly aware of the benefits biosimilars will bring to ... Yet the portion of the Guidance dealing ...
(Date:1/13/2017)... Research and Markets has announced the addition of the "Global ... ... CAGR of 16.83% during the period 2017-2021. The report ... market for 2017-2021. To calculate the market size, the report considers the ... also includes a a discussion of the key vendors operating in this ...
(Date:1/13/2017)... ... January 13, 2017 , ... FireflySci has been ... found among its diverse customer base. The latest entry in this field is ... including BTX and Bio-Rad. FireflySci is introducing three distinct varieties including a 10x1mm, ...
(Date:1/12/2017)... (PRWEB) , ... January 12, ... ... USING VTI’S INTERFUSE® IS A SUCCESS , VTI, Vertebral Technologies, Inc., announces ... the InterFuse® laterally expandable device. Since September 2016, VTI (Vertebral Technologies, Inc.) ...
Breaking Biology Technology:
Cached News: