HOME >> BIOLOGY >> NEWS
Researchers Discover Mechanism Of Cleft Palate Development

Researchers led by a team of UC San Francisco scientists have identified the mechanism by which a disfiguring birth defect wreaks its havoc. Cleft palate, the most common craniofacial birth defect in humans, occurs when the two sides of the palate do not properly fuse during fetal development, leaving an opening or cleft in the roof of the mouth.

Earlier research had already established that abnormalities in the gene for Transforming Growth Factor Alpha (TGF-a) were linked to cleft lip and palate syndromes. TGF-a is a growth factor with many known functions yet how it related to cleft palate was a mystery until now.

The inter-institutional group, led by Rik Derynck, PhD, UCSF professor of cell biology in the Department of Growth & Development, and Zena Werb, PhD, UCSF professor of cell biology in the Department of Anatomy, demonstrated that during normal embryonic development, docking of the molecule TGF-a with the Epidermal Growth Factor Receptor (EGFR), results in the production of a class of proteins called matrix metalloproteinases (MMPs).

Using "genetic knock-out" mice specially bred without the EGFR, the researchers learned that after activation of the EGFR, MMPs regulate the closure of the palate. Palate closure must be closely coordinated with the development of the lower jaw, a process regulated by MMPs. Simply put, if EGFR does not function properly when TGF-a joins with it, MMPs are not produced and cleft palates frequently result. The study is reported in the May 1999 issue of the journal Nature Genetics.

"This study has provided a developmental basis for the correlation between EGFR functioning and cleft palate syndrome but also illuminates the development mechanism for palate closure," says Derynck. "The role of this receptor in palate closure is through its ability to induce the activity of proteases. This is an intriguing finding because we believe that this animal study will translate very closely to humans."

With the
'"/>

Contact: James Larkin
jlarkin@pubaff.ucsf.edu
415-750-6633
University of California - San Francisco
1-May-1999


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... , ... July 15, 2019 , ... ... science expertise exclusively for Life Sciences and Healthcare companies, announces the availability of ... advisory services and strategic direction to start-up and emerging bio-pharma companies interested in ...
(Date:7/10/2019)... FRANCISCO (PRWEB) , ... July 10, 2019 , ... ... Intelligent Virtual Agents for sales and service organizations, today announced its role ... experience and streamline the operational efficiency of its franchisees. A key part of ...
(Date:7/5/2019)... Calif. (PRWEB) , ... July 05, 2019 , ... ... with Microsoft to bring its patented Tractus™ Platform to governments around the world. ... bring cutting edge technology and point of care solutions to operating theatres worldwide ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... July 08, 2019 , ... Today, at the BIO World Congress ... Association (NCGA) announced the winners of the Consider Corn Challenge II. Three winners ... field corn to produce biobased materials. , “Corn is a sustainable, abundant and ...
(Date:6/18/2019)... and SOMERSET, N.J. (PRWEB) , ... June 17, ... ... Biologics, today announced that they have entered into an agreement for production and ... candidates, IC-100 for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and ...
(Date:6/11/2019)... ... June 10, 2019 , ... Advancements ... an upcoming episode, scheduled to broadcast 4Q/2019. Check your local listings for more ... educate viewers about how its technology facilitates laboratories to improve efficiency and quality ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released ... cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene ... MSC-EVs also increased the cells’ ability to lodge into bone marrow. This research ...
Breaking Biology Technology:
Cached News: