HOME >> BIOLOGY >> NEWS
Researchers Document Transmission Of Protease-Resistant HIV

GENEVA, Switzerland -- A team of AIDS researchers has reported a case in which a person has become infected with HIV that is resistant to six of the 11 approved HIV anti-retroviral drugs, including protease inhibitors. The investigators are from the University of California San Francisco AIDS Research Institute, ViroLogic, Inc., and the Centers for Disease Control and Prevention

Protease inhibitors have been approved for two years, and as part of triple combination therapies, have contributed to a dramatic decline in AIDS death rates. Protease inhibitors block construction of proteins the virus needs to build more copies of itself.

Transmission of drug resistant HIV has been reported previously, but only to anti-retrovirals known as reverse transcriptase inhibitors, which work by blocking the replication of the virus. They have been in use for more than 10 years, but are less effective treatments.

The transmission of protease inhibitor resistant strains of HIV to a previously uninfected person could represent an emerging clinical and public health problem because protease inhibitors are a powerful weapon in the arsenal against HIV, said Frederick Hecht, MD, assistant clinical professor of medicine at the UCSF-affiliated San Francisco General Hospital, and lead author of the study. The case study was reported by Hecht here today (July 1) at the 12th World AIDS Conference. Research results also will be published in the New England Journal of Medicine, currently in press.

The multi-drug resistant HIV strain is believed to have been transmitted from one person to another through unprotected anal intercourse. Multiple mutations of HIV are required for the virus to become resistant to protease inhibitors, according to Hecht, and it had been thought that those mutations might make it more difficult for the virus to reproduce and make transmission between people less likely.

"We still don't know how frequently resistant strains are transmitted," he sa
'"/>

Contact: Mitzi Baker
mabaker@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
1-Jul-1998


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... 2020 , ... The field of quantitation of large molecules or proteins has ... area. However, the use of mass spectrometry in this field has gained a lot ... do you choose which approach to use (LBA or MS)?” In many cases, ...
(Date:6/19/2020)... ... June 18, 2020 , ... Join experts from Envigo ... in a live webinar on Wednesday, July 8, 2020 at 11am EDT ... we genetically engineer new models. However, while modifying the genome may be more straightforward, ...
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed ... well-being of our attendees, staff, and the public. We remain committed to creating ... ways to collaborate virtually,” said Julie Sutcliffe, President of WMIS. , ...
Breaking Biology News(10 mins):
(Date:6/2/2020)... ... June 01, 2020 , ... As part of its ongoing ... the world, enterprise security solutions provider bitsIO donated time to help two companies ... during self-quarantines and shelter-in-place orders, companies are increasingly concerned about the security of ...
(Date:5/28/2020)... Switzerland (PRWEB) , ... May 28, 2020 , ... ... biopharmaceutical R&D, today announced the release of Genedata Screener ® 17.0, the ... of screening data from all in-vitro screening assay technologies. Genedata will host a ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... trials will cause long-term harm , Contrary to conventional wisdom that says the ... finds many companies will emerge from the pandemic commercially weaker, dealing with ...
(Date:5/21/2020)... Calif. (PRWEB) , ... May 20, 2020 , ... ... the addition of Simon Prakash, who will serve as the company’s executive vice ... at a time when Exo is disrupting the medical imaging space, bringing more ...
Breaking Biology Technology:
Cached News: