The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Researchers Document Transmission Of Protease-Resistant HIV

irus to HIV anti-retrovirals.

Virologic's phenotypic analysis showed the patient's virus was resistant to two reverse transcriptase inhibitors: zidovudine (AZT) and lamivudine (3TC), and four protease inhibitors: saquinavir, ritonavir, indinavir, and nelfinavir. In addition, the researchers evaluated the viral genotype of the patient and the partner to determine whether mutations associated with resistance to anti-retrovirals were present. The patient's virus had four mutations associated with resistance to reverse transciptase inhibitors and seven associated with resistance to protease inhibitors.

Evaluation of the partner's virus showed many of the same mutations, while other genetic tests showed the virus in the patient closely matched that of the partner.

Because this patient's virus is resistant to many anti-retrovirals, typical drug combinations are not working as well as for other patients, Hecht said, but other treatment options still exist.

"This case doesn't mean that combination therapy is not a good thing," said Thomas J. Coates, PhD, director of the UCSF AIDS Research Institute. "A lot of people are living longer and better lives due to combination therapies, but it is clearly not the final answer. We have to help the afflicted communities understand that transmission of resistant strains is possible, even by a practice not considered to be very risky."

The patient was a part of the UCSF Options Project, a study evaluating the usefulness of combination therapy started soon after infection. The project is directed by James O. Kahn, MD, of the UCSF AIDS Program at San Francisco General Hospital.

Co-investigators in this study from the UCSF Gladstone Institute of Virology and Immunology are: Robert Grant, MD, MPH, staff research scientist and director of the UCSF/Gladstone Core Virology Lab; Laura Digilia, MD and Nirmala Bandrapalli, MS.

Other co-investigators are Beth Dillon, MSW, MPH, and Bernard Branson, MD, from the Centers f
'"/>

Contact: Mitzi Baker
mabaker@itsa.ucsf.edu
(415) 476-2557
University of California - San Francisco
1-Jul-1998


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Document Transmission Protease Resistant HIV

(Date:11/24/2009)...ors to understanding how sounds associated with Na...al or if they hear it at all. , The same type o...uses to detect flaws in the space shuttle,s behemo...o peek inside the giant head of a whale. The scans... of a whale,s hearing anatomy using a breakthrough...
(Date:11/24/2009)...arkable class of ring-shaped protein motors has be...eley National Laboratory (Berkeley Lab) using a st... the Advanced Light Source (ALS). These protein mo...lication, and are vital to the survival of all bio...as the human papillomavirus, which has been linked...
(Date:11/24/2009)...ng held secrets of the earth,s history locked in i...very little information on the environments that h...of years. Now, a team of researchers from nine ins...tune of $10 million dollars by the National Scienc...gs literally. These scientists will drill through...
Breaking Biology News(10 mins):Rocket science leads to new whale discovery 2Atomic-level snapshot catches protein motor in action 2Atomic-level snapshot catches protein motor in action 3Atomic-level snapshot catches protein motor in action 4LSU gets to the bottom of things -- in Antarctica 2Research Finds New Crop of Breast Cancer Genes 47543 1Research Finds New Crop of Breast Cancer Genes 47543 2New Study Documents High Prevalence of Serious Mental Illnesses Among Nations Jail Populations 47540 1New Study Documents High Prevalence of Serious Mental Illnesses Among Nations Jail Populations 47540 2Horizon Therapeutics HZT 501 Significantly Reduces Incidence of NSAID Induced Upper Gastrointestinal Ulcers in Patients With Mild to Moderate Pain 4506 1Horizon Therapeutics HZT 501 Significantly Reduces Incidence of NSAID Induced Upper Gastrointestinal Ulcers in Patients With Mild to Moderate Pain 4506 2Horizon Therapeutics HZT 501 Significantly Reduces Incidence of NSAID Induced Upper Gastrointestinal Ulcers in Patients With Mild to Moderate Pain 4506 3Horizon Therapeutics HZT 501 Significantly Reduces Incidence of NSAID Induced Upper Gastrointestinal Ulcers in Patients With Mild to Moderate Pain 4506 4Horizon Therapeutics HZT 501 Significantly Reduces Incidence of NSAID Induced Upper Gastrointestinal Ulcers in Patients With Mild to Moderate Pain 4506 5
(Date:11/24/2009).../PRNewswire/--HealthRoboticstodayannounced,thatith...ed,investors.ThisrecentlyformedToronto-basedcompan...andwillmarket,install,andsupport,HealthRobotics,i....onaryproductofferingsi.v.STATION(TM),i.v.SOFT(TM),...eassistanceonan"asneeded,basis"toitsstrategicpartn...
(Date:11/24/2009)...ire-FirstCall/--CellTherapeutics,Inc.(CTI)(Nasdaqa...erJaffrayHealthCareConference.Theconferencewillbeh... CTIwillpresentonTuesday,December1at11:00a.m.Easte...presentationwillbeavailableat www.celltherapeutics... , ,PiperJaffrayHealthCareConference,NewYorkPalac...
(Date:11/23/2009)...ltra-fast communication, computation and more powe...ying to use quantum states as carriers of informat...sicists have shown, mathematically, how to gently ... while keeping the information intact. Their work ...ew Letters and highlighted with a Viewpoint in P...
(Date:11/23/2009)...PRNewswire-FirstCall/-YMBioSciencesInc.(NYSEAmex: ...ythatidentifiesandadvancesadiverseportfolioofpromi...ment,todayreportedthatCytopia(ASX:CYT)hascommenced...t,orally-administeredJAK1/JAK2inhibitor.Thetrialis...roposaltomergeCytopiaintoYMhasbeenpreviouslyannoun...
Breaking Biology Technology:Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 2YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA 2YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA 3YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIA 4
Other News:
...e Department warnings against unnecessary travel i...and Albanian archaeologists launched a field study...heir quest is to learn more about a Greek colony t...C., but the team instead found an unexpected abund...
...rs at Columbia University have synthesized large q...lates with age in human eyes and may.contribute to... The Columbia team also was able to isolate a...including the vitamin A derivative, called A2E. .Q...
...y a UC San Francisco investigator have genetically...cing animals that exhibit anxiety, thereby.offerin...which the serotonin.brain system contributes to an...er 7 issue of Proceedings of the National.Academy ...
...el's most pressing but least known problems-what t...ssian scientists are designing a.cocktail of bacte...nts. The.resulting methane gas could be used to po... a revolution in the science of biodegradation," s...
Amid Albanian Turmoil, Archaeologists Unearth Secrets Of The Stone Age 2Amid Albanian Turmoil, Archaeologists Unearth Secrets Of The Stone Age 3Columbia Researchers Synthesize Compound With Possible Link To MacularDegeneration; Work Is Critical To Pinpointing Causes Of Disease, Scientists Say 2Columbia Researchers Synthesize Compound With Possible Link To MacularDegeneration; Work Is Critical To Pinpointing Causes Of Disease, Scientists Say 3Columbia Researchers Synthesize Compound With Possible Link To MacularDegeneration; Work Is Critical To Pinpointing Causes Of Disease, Scientists Say 4Genetically Engineered Mice Exhibit Anxiety, Offering Insight Into Role Of Serotonin In Brain 2Genetically Engineered Mice Exhibit Anxiety, Offering Insight Into Role Of Serotonin In Brain 3Genetically Engineered Mice Exhibit Anxiety, Offering Insight Into Role Of Serotonin In Brain 4
... While cardiovascular disease occurs in both men .... Risk factors and protective factors for heart di...sms responsible for these differences are so far u...linked genes or sexual hormones such as estrogen a...
...HCarnegie Mellon Universitys Peter J. Adams has be...ronmental Protection Agency (EPA) to study how glo...act U.S. air quality. Spyros Pandis, a chemical en... on the grant. ... Adams, an associate professor o...
...s are the worlds treasure houses of biodiversity, ... may be more evenly distributed in some forests th... management and preservation strategies. That is o... study of a lowland rainforest in New Guinea, publ...
...al plow-based agricultural methods and the need to...ning to deplete the Earth's soil supply, a new stu...es appear to increase soil erosion to the point th...ontgomery, a University of Washington professor of...
Cardio exercise benefits in male vs. female hearts 2Carnegie Mellon's Peter Adams receives EPA research grant 2Smithsonian scientists show differing patterns of rainforest biodiversity 2Smithsonian scientists show differing patterns of rainforest biodiversity 3Conventional plowing is 'skinning our agricultural fields' 2