HOME >> BIOLOGY >> NEWS
Researchers Find How Two Cancer Genes Interact To Cause Malignancy

DURHAM, N.C. -- Researchers at Duke University Medical Center have discovered how two cancer-causing genes can interact to transform normal cells into cancerous cells, adding further insight into the long-held theory that cancers require mutations in multiple genes.

In a paper published in the Feb. 26 issue of Molecular Cell, geneticist Joseph Nevins and his colleagues report details of the functional interaction between the proteins produced by two cancer-related genes, called "myc" and "ras."

Basically, the researchers discovered that mutated ras causes the protein from myc to accumulate in the cell, enhancing myc's growth-promoting abilities. If ras is not mutated, the myc growth-stimulating signal dies rapidly and cellular replication is controlled.

"The 'multi-hit' notion of cancer has been around for a while," said Nevins, a Howard Hughes Medical Institute Investigator at Duke. "In the mid 1980s scientists showed that if both myc and ras were mutated, the cells became cancerous. Until now there has been little mechanistic information as to how these two genes work together."

The researchers' report shows that the myc protein lasts five times longer than normal if ras is mutated. This information could eventually affect treatment and diagnosis of many cancers, including brain, colorectal and endometrial (uterine). Tumor cells with mutations in both myc and ras are likely to have an even more dramatic increase in the duration of the myc growth signal, Nevins said.

"The key to developing better therapeutics for cancer," said Nevins, "is using the information learned about interactions such as that of ras with myc to design drugs that interfere with these oncogenic processes." Like all so-called oncogenes, myc and ras perform important cell functions when normal, but act as accelerators to spur uncontrolled cell proliferation when mutated. In normal cells, the amount of protein produced by the myc gene increases to promote cell growth and
'"/>

Contact: Joanna Downer
Downe010@mc.duke.edu
919-684-4148
Duke University Medical Center
25-Feb-1999


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... 03, 2020 , ... Litmus Health , the research-ready ... of the company’s security practices has been completed. The assessment deemed Litmus infrastructure ... evaluation reviewed Litmus’ processes and systems, assessing them to see whether they adhere ...
(Date:8/26/2020)... ... August 25, 2020 , ... ... developing novel pharmaceuticals targeting mitochondria, in partnership with Essex Bio-Technology, a bio-pharmaceutical ... pivotal U.S. Phase 3 VISTA-2 study of SkQ1 ophthalmic solution in patients ...
(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, a biopharmaceutical cold ... Inc. 5000 list. The list is the most prestigious ranking of the nation’s fastest-growing ... for this year’s list, reported three-year revenue growth of 71 percent. , The ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its platform ... Biologics since its formation in 2016, the company is relaunching itself under the Ardent ... its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has introduced new ... for use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical ... requirements, performance, and cost criteria; especially where solid wire is limited. Typical configurations ...
(Date:7/31/2020)... , ... July 30, 2020 ... ... cloud-based software for the life sciences industry, today announced the release of ... designed specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... Ohio (PRWEB) , ... July 16, 2020 , ... ... data solutions to aid in the early detection and prevention of high-burden diseases, ... to enable US-based hospitals and healthcare organizations to utilize existing data in order ...
Breaking Biology Technology:
Cached News: