HOME >> BIOLOGY >> NEWS
Researchers Identify And Isolate First Gene For A Form Of Insulin-Dependent Diabetes

St. Louis, Oct. 1, 1998 -- Reporting in the Oct. 1 issue of the journal Nature Genetics, investigators at Washington University School of Medicine in St. Louis say they have identified the first gene known to cause a form of insulin-dependent diabetes in children.

Studying blood samples from six families affected by the disorder, the investigators found that mutations in a gene on chromosome 4 cause a disorder called Wolfram Syndrome. The disorder is characterized by insulin-dependent diabetes and vision problems, with eventual blindness. The syndrome also can include diabetes insipidus, a pituitary gland disorder associated with intense thirst and the need to excrete large amounts of urine. Some people with Wolfram Syndrome also lose their hearing.

The disorder is caused by mutations in a single gene called WFS1, the researchers found. Identification of that gene could provide important information about several disorders, but the investigators are particularly excited about how it might affect the understanding and treatment of the more common forms of diabetes, which affect more than 20 million people in the United States.

"We know that mutations in several genes predispose a person to diabetes, but unlike this one, they do not cause the disease," explained senior investigator M. Alan Permutt, M.D., professor of medicine. "If you have a mutation in this Wolfram gene, you get diabetes. So I believe this is the first gene that, when mutated, clearly leads to insulin-dependent diabetes."

Wolfram Syndrome is a rare form of insulin-dependent diabetes that strikes children at about age 6. By age 8 or 10, the children also develop visual impairment and subsequently go blind. Most suffer from progressive neurodegeneration and die in their 30s.

Since Wolfram Syndrome was identified more than 60 years ago, researchers had suspected that it was inherited. Often, parents of affected children are related to
'"/>

Contact: Jim Dryden
dryden@medicine.wustl.edu
(314) 286-0110
Washington University School of Medicine
29-Sep-1998


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2020)... TORONTO (PRWEB) , ... July 17, 2020 , ... Commercial ... hangs on pharma’s ability to discover a COVID cure or vaccine, the global economic ... competitive and price pressure is not going away and capturing full value from every ...
(Date:7/2/2020)... (PRWEB) , ... July 02, ... ... Biology Systems, B.V. (MBS) has announced a publication detailing the use of ... reverse transcription polymerase chain reaction (RT-PCR) in 16 minutes. The article, titled ...
(Date:6/25/2020)... ... June 24, 2020 , ... ... software-driven clinical data services that accelerate drug development, is collaborating with Karyopharm Therapeutics ... inhibitor, in hospitalized patients with severe COVID-19. This is the first study of ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... DuPont Nutrition & ... Wuxi, China. The new plant operation will provide the local animal production industry ... , “This facility will improve the flexibility of our offerings to the Chinese ...
(Date:8/12/2020)... ... August 11, 2020 , ... The ... the Facioscapulohumeral Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with ... network is a consortium of academic research centers in the United States and ...
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, ... it has closed on the purchase of greenfield for a new, expanded manufacturing ... includes over 21 acres in the initial acquisition, with an option to purchase ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now ... With 50 million stem cells total, patients may choose which extremities they would like ... arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained ...
Breaking Biology Technology:
Cached News: