Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger

UC San Francisco researchers may have identified the way in which a protein that regulates genes involved in sexual differentiation, reproductive development and stress is, itself, activated.

If verified, the finding would signify a major breakthrough in understanding the modulation of a key regulator of the genes involved in such endocrine activities as the determination of sex, the development of sex organs and the way the body reacts to stress.

The finding could also, perhaps, be applied more generally, possibly explaining why some hormonally regulated cancers, such as of the breast and prostate, at times become resistant to anti-hormone therapies. For it suggests a possible alternative mechanism of action on these nuclear receptors in some cancer cells.

The finding, reported in the current issue of Molecular Cell, confirms what researchers have long suspected but been unable to prove - that the protein, a nuclear receptor known as steroidogenic factor 1, is regulated not by the "small molecule" hormones that regulate all other known nuclear receptors, but by a signaling cascade that culminates in phosphorylation, the addition of a phosphorous molecule to the receptor.

Nuclear receptors are a sophisticated brand of cellular proteins located inside the nucleus, where they receive signals and interact with other proteins to initiate changes in gene activity. The small-molecule hormones, or "ligands," that regulate most of these nuclear receptors sweep into a cell's nucleus from far-flung cells and latch on to their respective receptor, prompting it to bind with nearby molecular "co-factors." Together, the receptor and its co-factors bring about the change in a given gene's behavior.

The molecule, or ligand, that signals the SF-1 nuclear receptor to prompt a change in gene activity has been elusive, however, leading to its designation as an "orphan" receptor, and leaving researchers suspicious that some signal other than a small-molecule h

Contact: Jennifer O'Brien
University of California - San Francisco

Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:8/12/2020)... ... August 12, 2020 , ... ... that are ideal for public health agencies of all sizes. With a focus ... helping at-risk individuals find appropriate health care, Mosio helps public health departments automate ...
(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval ... CoreText™ and ProText™, making them the first Wharton’s jelly allografts to be assigned a ... The company’s solutions are the first Wharton’s jelly allograft product to be recognized as ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead upcoming ... term focus on Type 2 diabetes and associated comorbidities. , Justin brings over ... and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... ... manufacturing capability in Wuxi, China. The new plant operation will provide the local ... advanced technology. , “This facility will improve the flexibility of our offerings ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... (EMMA International), a global leader in FDA compliance consulting has been named on ... private companies. The list represents a unique look at the most successful companies ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader in ... “BUILDING FOR LIFE.” The adoption of this taglines comes at a time of ... capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical treatments. ...
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® Respiratory ... 16 countries, has reached its 20th anniversary of worldwide use. Introduced in the ... top universities including University of Pennsylvania, University of Michigan, University of Maryland, University ...
Breaking Biology Technology:
Cached News: