Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger

UC San Francisco researchers may have identified the way in which a protein that regulates genes involved in sexual differentiation, reproductive development and stress is, itself, activated.

If verified, the finding would signify a major breakthrough in understanding the modulation of a key regulator of the genes involved in such endocrine activities as the determination of sex, the development of sex organs and the way the body reacts to stress.

The finding could also, perhaps, be applied more generally, possibly explaining why some hormonally regulated cancers, such as of the breast and prostate, at times become resistant to anti-hormone therapies. For it suggests a possible alternative mechanism of action on these nuclear receptors in some cancer cells.

The finding, reported in the current issue of Molecular Cell, confirms what researchers have long suspected but been unable to prove - that the protein, a nuclear receptor known as steroidogenic factor 1, is regulated not by the "small molecule" hormones that regulate all other known nuclear receptors, but by a signaling cascade that culminates in phosphorylation, the addition of a phosphorous molecule to the receptor.

Nuclear receptors are a sophisticated brand of cellular proteins located inside the nucleus, where they receive signals and interact with other proteins to initiate changes in gene activity. The small-molecule hormones, or "ligands," that regulate most of these nuclear receptors sweep into a cell's nucleus from far-flung cells and latch on to their respective receptor, prompting it to bind with nearby molecular "co-factors." Together, the receptor and its co-factors bring about the change in a given gene's behavior.

The molecule, or ligand, that signals the SF-1 nuclear receptor to prompt a change in gene activity has been elusive, however, leading to its designation as an "orphan" receptor, and leaving researchers suspicious that some signal other than a small-molecule h

Contact: Jennifer O'Brien
University of California - San Francisco

Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:8/21/2019)... (PRWEB) , ... August 21, 2019 , ... ... E. coli cell line for rapid and low-cost biomanufacturing of complex protein therapeutics, ... Formerly a member of AbSci's Scientific Advisory Board, Dr. Larimore brings more than ...
(Date:8/15/2019)... ... August 15, 2019 , ... Deep Science Ventures ... Food and Agriculture practice, a new unit dedicated to building 100 companies over the ... raw materials and supply chains. , Deep Science Ventures was founded to create ...
(Date:8/14/2019)... ... August 14, 2019 , ... Carterra® ... they have opened a Customer Experience Center (CEC) and office in Munich, Germany. ... office. , The Munich CEC will be a place for researchers throughout Europe ...
Breaking Biology News(10 mins):
(Date:9/4/2019)... N.J. (PRWEB) , ... September ... ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, ... Ph.D., Director, Science & Technology will present at the upcoming Nordic Life ...
(Date:8/29/2019)... ... August 28, 2019 , ... DuPont Nutrition & Biosciences ... attendees at the International Baking Industry Expo, September 8 to 11, in booth ... efficiency to cost and waste reduction and from maintaining freshness throughout shelf life ...
(Date:8/27/2019)... ... August 27, 2019 , ... Modality ... announce it has promoted Consulting Engineer, Robert Battista, to Senior Consulting engineer. , ... of onboarding and mentoring new engineers as well as the creation of additional ...
(Date:8/23/2019)... ... August 22, 2019 , ... An ... and is scheduled to broadcast 4Q/2019. Check your local listings for more information. ... for generic drug delivery. Focusing on therapeutics for children and the elderly, viewers ...
Breaking Biology Technology:
Cached News: