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Researchers Isolate Gene For Heart And Facial Defects

as a neighboring gene, CDC45, missing. However, the scientists feel that it is unlikely that CDC45 is involved in this syndrome because it is active in all cells.

"This paper represents a unique combination of studies," said Srivastava. "Dissection of a molecular pathway regulating embryogenesis in mice led to the identification of a human disease gene. This study will help us to further understand the mechanisms that control cardiac and craniofacial development."

Other UT Southwestern researchers participating in this study were pediatric research fellows Dr. Hiroyuki Yamagishi and Dr. Vidu Garg, and Tiffani Thomas, a research assistant in pediatrics. Dr. Rumiko Matsuoka of the Heart Institute of Japan at Tokyo Women's Medical University also was a co-author.


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Contact: Heather Stieglitz
heather.stieglitz@email.swmed.edu
214-648-3404
UT Southwestern Medical Center
19-Feb-1999


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