HOME >> BIOLOGY >> NEWS
Researchers Make Breakthrough In Gene Transfer

St. Louis, Oct. 21, 1998 -- Scientists often use the genetic material of viruses to smuggle foreign genes into cells. But such vectors frequently kill the cells they enter, limiting their long-term utility. For the first time, researchers at Washington University School of Medicine in St. Louis have devised a way to create harmless vectors from a harmful virus. In a paper in the Oct. 27 issue of Proceedings of the National Academy of Sciences, they show that the vectors are efficient couriers of genes.

"A similar strategy might work for modifying other cytotoxic viruses that are being used as gene vectors," says Charles M. Rice, Ph.D., professor of molecular microbiology and head of the research team. Postdoctoral fellow Eugene V. Agapov, M.D., Ph.D., and Ilya Frolov, Ph.D., research assistant professor of molecular microbiology, were the paper's lead authors.

By transferring foreign genes into cultured cells, scientists can study the regulation and functions of those genes under controlled conditions. They also can alter the activities of cells, to compensate for a defective gene, for example. Commenting on Rice's paper in an accompanying article, Peter Palese, Ph.D., of Mount Sinai School of Medicine, says that the "long-term expression of foreign proteins in a noncytotoxic manner may blow new wind into the sails of our gene therapy enterprise." This new type of vector might eventually be used to deliver DNA vaccines, he also suggests.

Rice and colleagues worked with Sindbis virus, which produces fever, headache and musculoskeletal symptoms. The virus's genetic material is a single strand of RNA, which Washington University research groups engineered into a gene vector in 1989.

To obtain vectors that will not kill cells, the researchers first inserted an extra gene into modified pieces of Sindbis RNA. The gene coded for a protein that inactivates puromycin
'"/>

Contact: Linda Sage
sage@medicine.WUSTL.edu
314-286-0119
Washington University School of Medicine
27-Oct-1998


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced Design ... will feature emerging and evolving technology through its ... Summits will run alongside the expo portion of the ... panels and demonstrations focused on trending topics within 3D ... design and manufacturing event will take place June 13-15, 2017 ...
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive ... a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness ... targeting the needs of consumers who are incorporating medical marijuana into their wellness ... Arizona. , As operators of two successful Valley dispensaries, The Giving Tree’s two ...
(Date:10/6/2017)... Mass. (PRWEB) , ... October 06, 2017 , ... ... female entrepreneurship within the healthcare and technology sector at their fourth annual Conference ... panels featuring 30 inspiring speakers and the ELEVATE pitch competition showcasing early stage ...
Breaking Biology Technology:
Cached News: