Researchers Prove Chemoprevention Can Work

A team of researchers has shown that a certain type of chemoprevention used to experimentally deter liver cancer from developing is effective. The researchers gave the drug oltipraz, originally developed to treat schistosomiasis, to a group of people at high risk for developing liver cancer. The oltipraz changed the way in which the study group metabolized aflatoxin, a liver carcinogen produced by a fungus that contaminates foods like corn and peanuts.

They were able to show that the oltipraz induced phase 2 enzymes which altered the disposition of aflatoxin in the study group. This was the first time that the mechanism by which this chemopreventive agent worked was identified and confirmed with human subjects. The study establishes proof of principle that chemo-preventive agents can work by changing the disposition of environmental carcinogens. It appears in the February 17, 1999 issue of the Journal of the National Cancer Institute.

Liver cancer is a major cause of cancer deaths worldwide and claims approximately 400,000 lives in China each year. It is one of the fastest growing cancers in the United States and is also a problem in Canada which has large numbers of Chinese immigrants. Two of the major risk factors for liver cancer in China are infection with hepatitis B and aflatoxin in the diet. Aflatoxins are produced by some strains of the Aspergillus fungi and are found in much of the food supply in certain parts of China. They are commonly found in corn, peanuts, soya sauce, and fermented soy beans.

Senior author Thomas Kensler, PhD, professor, Environmental Health Sciences, said, "We know a lot about how aflatoxin works. We were able to develop the analytic tools to measure aflatoxin elimination, and that enabled us to see if oltipraz made a difference in that process." Lead author Jia-Sheng Wang MD, PhD, research associate, Environmental Health Sciences

Contact: Kathy Moore
Johns Hopkins University Bloomberg School of Public Health

Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:9/17/2019)... Bar, CA (PRWEB) , ... September 17, 2019 ... ... Kim, recently presented at the 27th Series of the Australia Society of Implant ... an Implant Surgeon’s Perspective,” was part of the Surgical Aspects of Modern Implant ...
(Date:9/14/2019)... ... 13, 2019 , ... Two studies presented at the annual ... of gene therapy and advances to decrease nerve damage using Fluorescence image-guided surgery. ... storage diseases (LSD) are among the most dismal of prognosis in all of ...
(Date:9/11/2019)... ... September 10, 2019 , ... Newly released ... an unusual collaboration that offers a beautiful and thought-provoking journey through five chapters ... Srinivasan painted to Whittaker’s poems and other times, Whittaker wrote to Srinivasan’s paintings. ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... September 24, 2019 , ... Drug resistance has been ... World Health Organization, with MRSA becoming one of the most serious concerns. Hong Kong ... reported cases of community-associated MRSA (CA-MRSA), or a seven-fold of the figure in 2007 ...
(Date:9/22/2019)... ... September 20, 2019 , ... ... Neurotrophic Factor (BDNF) testing in serum . BDNF plays a vital role in ... growth and differentiation of new neurons in the brain involved in learning, memory, ...
(Date:9/17/2019)... ... September 16, 2019 , ... When a lot of researchers think of ... the complete 3D characterization of tissues through the use of confocal and light sheet ... analysis and advanced cell culture focused contract research organization and today offers 3D ...
(Date:9/11/2019)... ... September 10, 2019 , ... An upcoming ... the latest developments in genome sequencing analysis. Check your local listings for more ... at Rivermap Research & Consulting and will explore its revolutionary pathogenic DNA analysis ...
Breaking Biology Technology:
Cached News: