Researchers Report Emergence Of Antibiotic Resistance During Vancomycin Therapy

Antibiotic Combination Shown To Be Effective Against Resistant Bug

A team of researchers led by The Rockefeller University's Alexander Tomasz, Ph.D., have described the case of a 79-year-old patient whose death in a New York metropolitan area hospital last March was associated with a bloodstream infection caused by a multidrug-resistant strain of Staphylococcus aureus. The report, published in the Feb. 18 issue of the New England Journal of Medicine (NEJM), showed that the bacteria, which had decreased susceptibility to vancomycin, could be treated effectively with a combination of antibiotics.

"We think that this is the first demonstration that selection for strains with increased resistance to vancomycin can occur during therapy," says Tomasz, senior author of the paper and professor and head of the Laboratory of Microbiology.

The case described in the NEJM article was the fourth in the world associated with infections caused by multiresistant strains of Staphylococcus aureus (MRSA) that also show partial resistance to vancomycin, a drug often described as the "last resort" antibiotic against these dangerous pathogens that cause many hospital-acquired infections in the United States and elsewhere.

"The emergence of vancomycin-resistant Staphylococcus aureus strains emphasizes the importance vancomycin dosing to assure complete eradication of the bacteria", says Richard B. Roberts, M.D., a co-author of the report and an adjunct professor at Rockefeller and professor of medicine at New York Hospital-Cornell Medical Center.

A hopeful finding reported by the Rockefeller team is that a combination of two commonly used antibiotics, oxacillin and vancomycin, produced a synergistic effect and killed the vancomycin-resistant MRSA very efficiently in the test tube.

"If these results can be translated into the clinical setting, they suggest that a combination of vancomycin and oxacillin may be an effective therapeutic regimen against vanco

Contact: Joseph Bonner
Rockefeller University

Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: