HOME >> BIOLOGY >> NEWS
Researchers Report Emergence Of Antibiotic Resistance During Vancomycin Therapy

Antibiotic Combination Shown To Be Effective Against Resistant Bug

A team of researchers led by The Rockefeller University's Alexander Tomasz, Ph.D., have described the case of a 79-year-old patient whose death in a New York metropolitan area hospital last March was associated with a bloodstream infection caused by a multidrug-resistant strain of Staphylococcus aureus. The report, published in the Feb. 18 issue of the New England Journal of Medicine (NEJM), showed that the bacteria, which had decreased susceptibility to vancomycin, could be treated effectively with a combination of antibiotics.

"We think that this is the first demonstration that selection for strains with increased resistance to vancomycin can occur during therapy," says Tomasz, senior author of the paper and professor and head of the Laboratory of Microbiology.

The case described in the NEJM article was the fourth in the world associated with infections caused by multiresistant strains of Staphylococcus aureus (MRSA) that also show partial resistance to vancomycin, a drug often described as the "last resort" antibiotic against these dangerous pathogens that cause many hospital-acquired infections in the United States and elsewhere.

"The emergence of vancomycin-resistant Staphylococcus aureus strains emphasizes the importance vancomycin dosing to assure complete eradication of the bacteria", says Richard B. Roberts, M.D., a co-author of the report and an adjunct professor at Rockefeller and professor of medicine at New York Hospital-Cornell Medical Center.

A hopeful finding reported by the Rockefeller team is that a combination of two commonly used antibiotics, oxacillin and vancomycin, produced a synergistic effect and killed the vancomycin-resistant MRSA very efficiently in the test tube.

"If these results can be translated into the clinical setting, they suggest that a combination of vancomycin and oxacillin may be an effective therapeutic regimen against vanco
'"/>

Contact: Joseph Bonner
runews@rockvax.rockefeller.edu
212-327-7900
Rockefeller University
18-Feb-1999


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/14/2019)... ... November 13, 2019 , ... NDA Partners Chairman Carl ... affairs and program management executive with more than 33 years of regulatory and ... firm as an Expert Consultant. , Robert Peterson has extensive experience in ...
(Date:11/12/2019)... ... 12, 2019 , ... The Arnold and Mabel Beckman Foundation ... institutions for its Instrumentation Grant for Advanced Light-Sheet Microscopy and Data Science ... for the acquisition of instrumentation, development and maintenance; support for data science collaborations ...
(Date:11/7/2019)... ... , ... R3 Stem Cell is now offering its comprehensive Online Stem ... to use during checkout is FIFTYOFF and applies to both the one month access ... therapies with over 12,000 successful stem cell procedures performed nationwide. A couple years ago, ...
Breaking Biology News(10 mins):
(Date:11/12/2019)... ... November 12, 2019 , ... ... software solutions for biopharmaceutical R&D, today announced that Immatics Biotechnologies , ... Genedata Biologics® to streamline their R&D operations related to the ...
(Date:11/9/2019)... ... November 08, 2019 , ... ... pathology research, today announced the results of analyses examining the severity of ... phase 3 selonsertib studies (STELLAR). Strong correlations were demonstrated between AI-powered and ...
(Date:11/5/2019)... ... November 05, 2019 , ... Focal Healthcare ... Mark for its Fusion Bx 2.0 prostate fusion biopsy solution. By combining information ... Bx 2.0 will give urologists across Europe the ability to perform targeted transrectal ...
(Date:11/2/2019)... ... October 31, 2019 , ... drug360 graph, ... pioneer tellic. drug360 brings tellic’s expertise in biomedical language processing and machine ... quickly uncover relationships between genes, diseases, variants, phenotypes, and other biomedical entities. ...
Breaking Biology Technology:
Cached News: