HOME >> BIOLOGY >> NEWS
Researchers Show Mechanism And Similarities Of Biological Clocks

Scientists picking apart the inner workings of the biological clocks that govern the daily cycles of life have now identified several key cogs of the machinery and have shown that these main parts are remarkably similar between invertebrates and mammals.

In the June 5 issue of Science, one team describes the working parts that drive the clock in mice forward like a watch spring, and in another paper another team for the first time identifies the gene in fruit flies that corresponds to the mammalian Clock gene and shows how it can turn itself off again, enabling it to oscillate like a pendulum.

"We always thought that circadian clocks might work the same way in different organisms, but this is really the first evidence -- with the same genes playing the same role in flies and mice," says Joseph S. Takahashi, professor of neurobiology and physiology at Northwestern University, who is an author on both papers and last year was the first to clone the mammalian clock gene.

"We now have three different circadian clock genes that are conserved between insects and mammals," Takahashi said. "These genes define a surprisingly simple and elegant feedback loop of gene activation and inhibition that composes the core mechanism of the clock in animals."

In the first paper, Charles Weitz and coworkers at Harvard Medical School, with Takahashi's group at Northwestern, searched for and identified a protein molecule that can bind to the protein, CLOCK, produced by the mouse Clock gene. This protein molecule, called BMAL1, is produced at the same time and in the same regions of the brain as the CLOCK protein.

The CLOCK-BMAL1 pair, they showed, is capable of binding to and turning on a genetic switch that regulates another gene, which is called mper-1 because it is the mammalian version of the period gene, which is required for circadian rhythm in flies.

"We think this 'on' mechanism accounts for the positive compone
'"/>

Contact: Bill Burton
b-burton@nwu.edu
847-491-3115
Northwestern University
5-Jun-1998


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... 2017 Janice Kephart , former ... Strategy Partners, LLP (IdSP) , today issues the ... Trump,s March 6, 2017 Executive Order: Protecting ... can be instilled with greater confidence, enabling the ... refugee applications are suspended by until at least ...
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
(Date:10/11/2017)... ... 2017 , ... Proscia Inc ., a data solutions ... “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, Managing ... how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... CALIF. (PRWEB) , ... October 10, 2017 , ... San ... part of its corporate rebranding initiative announced today. The bold new look is ... reach, as the company moves into a significant growth period. , It will also ...
Breaking Biology Technology:
Cached News: