HOME >> BIOLOGY >> NEWS
Researchers Take Major Step Toward Cracking Ebola Code

ANN ARBOR---Ebola is an extremely lethal virus that has frustrated the medical world's attempts to learn how it works. Now, researchers are gaining valuable insight into how Ebola wreaks its deadly havoc.

Investigators from the University of Michigan Medical School, the Howard Hughes Medical Institute and the Centers for Disease Control and Prevention found that Ebola works by waging a war on two fronts. Their results are published in the Feb. 13 issue of the journal Science.

Ebola virus causes a rapidly progressing, often fatal, infection that can lead to vomiting, diarrhea, rash, high fever, hemorrhaging and shock. Often, liver and kidney functions are impaired.

The research team, led by Gary Nabel, M.D., Ph.D., professor of internal medicine and biological chemistry at the U-M Health System and an investigator at the Howard Hughes Medical Institute, reports that the virus employs a glycoprotein (a protein with sugar attached) in two different ways to disable the immune response and attack certain cells.

Study results show the glycoprotein, secreted by the virus, appears to interfere with the inflammatory response that is used at a cellular level to fight off the virus. Another form of this glycoprotein stays bound to the Ebola virus and attaches itself to endothelial cells which line blood vessels, likely causing the hemorrhaging characteristic of Ebola.

This particular glycoprotein was found in Ebola virus by investigators at the CDC nearly 20 years ago, but its role in Ebola's cellular invasion remained a mystery.

Nabel and his team, tracked the glycoprotein in two ways. The secreted glycoprotein was detected by its ability to bind to cells, using an antibody to this viral gene product. The binding characteristic of the transmembrane (or virus-bound) form of the protein was detected by using a technique of molecular genetics to insert this protein o
'"/>

Contact: Pete Barkey
pbarkey@umich.edu
(313) 764-2220
University of Michigan
16-Feb-1998


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/1/2018)... ... 01, 2018 , ... NanoValent Pharmaceuticals, Inc ., (NanoValent) ... therapeutics, today announced the National Institute of Health (NIH) Small ... funding for two separate grants. These two grants will allow NanoValent to advance ...
(Date:10/1/2018)... ... October 01, 2018 , ... Despite U.S. nursing and assisted ... surrounding such facilities are dire. Lawsuits dot the news landscape including the 2017 ... chain’s “callous and profit-driven approach” has had “devastating” consequences for its California residents, ...
(Date:9/28/2018)... ... September 28, 2018 , ... Purification , The fluorescent-dye labeled bacmid ... QIAquick® PCR Purification Kit. Samples were gently mixed with 275 µL of provided PB ... 1 minute at room temperature. Flow-through was discarded and 750 µL of provided PE ...
Breaking Biology News(10 mins):
(Date:9/15/2018)... ... September 14, 2018 , ... Next-generation genomic sequencing is transforming ... new technologies, challenges remain. In the past, the sheer size of genomics data has ... is a new data ecosystem developed to advance cures by reducing the technological barriers ...
(Date:9/13/2018)... ... 2018 , ... Asymmetrex’s director, James L. Sherley, M.D., Ph.D., asks ... if we didn’t have the means to measure the number of drug molecules in ... And that is what’s holding up progress in stem cell medicine.” , “Can you ...
(Date:9/12/2018)... ... September 11, 2018 , ... Leading regenerative veterinary medicine ... Practitioners Conference (AAFP) later this month. The company’s CEO and founder, ... the treatment of chronic kidney disease in felines at a poster session on ...
(Date:9/12/2018)... ROCHELLE, Va. (PRWEB) , ... September 12, 2018 ... ... that Lauren Bronich-Hall, a quality management professional and former Senior Director of Regulatory ... Expert Consultant. , As Senior Director of Regulatory Affairs and Quality Systems ...
Breaking Biology Technology:
Cached News: