Researchers Unable To Document Existence Of Transient HIV Infection In Infants

Research published this week in the journal Science failed to verify even one case of transient infection among 42 cases where infants showed evidence of HIV-1 infection contracted from their mothers, but somehow became free of the virus that causes AIDS. The researchers concluded that laboratory errors created false readings when the specimens were initially tested.

"The study of transient HIV-1 infection draws attention because of clues it might give to development of a vaccine," said principal investigator Dr. Lisa M. Frenkel, associate professor of pediatrics and laboratory medicine at the University of Washington and Children's Hospital and Regional Medical Center in Seattle. "If individuals can be identified who have transient HIV-1 infection, a study of their immune responses could give clues as to what type of immune response could protect against or eliminate the infection."

To study cases of possible transient HIV-1 infection, Frenkel and colleagues looked to exposed infants, because, in contrast to adults, the time of exposure and the source of the virus are known: from an HIV-positive mother during the birth process. This knowledge allowed blood samples taken close to the time of exposure to be studied. When virus was found, results could be verified with genetic tests.

Frenkel explains the genesis for the current research: A few years ago, she and colleagues were studying the resistance of HIV to the AIDS drug, AZT. In their research, they encountered the case of a mother who had had two positive cultures for HIV, and her baby, who had tested positive three times. During later testing, HIV could not be found in their blood specimens. "It looked as if we had a case where both the mother and infant were transiently infected," said Frenkel.

To evaluate this case, the researchers re-analyzed the test results of these two and other reported cases. In addition to the mother and child, they found another 4

Contact: Laurie McHale
(206) 543-3620
University of Washington

Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:11/15/2018)... , ... November 14, 2018 , ... ... developed a tool that speeds up the analysis and publication of biomedical data ... results of their studies. Until now, the primary method available to share biomedical ...
(Date:11/15/2018)... (PRWEB) , ... November 14, 2018 , ... ... genetics testing lab, will present new scientific evidence on gene-disease relationships and how ... Annual Meeting to be held in Atlanta, November 14-17. , Ambry has ...
(Date:11/13/2018)... EAST NORRITON, Pa. (PRWEB) , ... November 13, ... ... and Chief Executive Officer Jonathan Retano will be a featured presenter at the ... the company will host a hospitality suite on Friday, November 16, where conference ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... (PRWEB) , ... November 13, 2018 , ... Renowned Honolulu ... patients on the island of Kauai. Dr. Leadbeater, of Kahala Pet Hospital ... since 2009. Recently, he began traveling to the island of Kauai on an ...
(Date:11/13/2018)... (PRWEB) , ... November 13, 2018 , ... ... Bio-Logic Aqua® Research Water Life Science® in Grants Pass, Oregon believes in the ... and Bio-Logic Aqua® Research Water Life Science® sponsors the Power of Water® on ...
(Date:11/7/2018)... ... 07, 2018 , ... Since September of this year, stem ... the adult tissue stem cell counting problem in stem cell medicine and the ... this effort with new educational publications and presentations at clinical trial supply conferences, ...
(Date:11/5/2018)... ... November 05, 2018 , ... GlycoMark, Inc., the ... professionals through its website, http://www.glycomark.com , as part of National Diabetes Month. ... option via the website in November from 9 a.m. – 5 p.m. ET ...
Breaking Biology Technology:
Cached News: