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Researchers Unable To Document Existence Of Transient HIV Infection In Infants

om among a large number of cases, we couldn't prove transient infection in any of them. Either the specimens were mixed up, or there was contamination from one specimen to another in the laboratory."

The researchers suggest that to confirm transient infection, viral strains in the donor must be genetically linked to viral strains in the recipient. They recommend using separate laboratories to evaluate donor and recipient specimens, with reagents prepared separately by different personnel.

"Our negative studies . . . indicate that the phenomenon of transient HIV-1 infection remains to be proven and that most cases suggestive of transient HIV-1 infection are cases of mislabeling of specimens or their contamination in the laboratory," state the authors.

Co-authors include researchers from the University of Washington, U.S. Centers for Disease Control and Prevention, Medical and Health Research Association of New York City, University of Rochester, University of Texas Medical Branch, University of Minnesota, Northwestern University, University of California at Los Angeles, Aaron Diamond AIDS Research Center, Santa Fe Institute, Roche Molecular Diagnostics and New York University North Shore Hospital.

The research was supported by grants from the Pediatric AIDS Foundation, the U.S. Public Health Service and the Foster Foundation.


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Contact: Laurie McHale
lmchale@u.washington.edu
(206) 543-3620
University of Washington
14-May-1998


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