ole animals, is that in future incarnations, the strategy can be modified to silence the expression of genes in specific tissues, and it can be designed to be switched on and off at any time during the development or adulthood of the animal. These and other features of the strategy, as well as combining it with drug discovery and other methods, should enable scientists to uncover a great deal of information about how genes influence many normal and pathological processes.

Although the current study targeted a gene thought to be involved in DNA repair, any gene would have sufficed as a target to demonstrate proof of principle as this study has done.

The creation of germline transgenic mice with heritable RNAi opens the door to the manipulation of gene activity in living animals for many applications.

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Contact: Peter Sherwood
sherwood@cshl.edu
516-367-6947
Cold Spring Harbor Laboratory
19-Jan-2003

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