Researchers at Children's Hospital of Philadelphia play major role in genetic milestone - first ,,full sequencing of a human chromosome

Philadelphia, Pa. - Researchers at The Children's Hospital of Philadelphia, where hundreds of children are treated each year for genetic diseases, played a major role in today's landmark announcement of the first sequencing of a complete human chromosome. Building on their previous work in producing a general map of chromosome 22, The Children's Hospital of Philadelphia research team processed large numbers of DNA segments from that chromosome in preparation for the sequencing. The Hospital is considered a world leader in caring for children with a genetic disorder that results from a defect of chromosome 22.

A significant event in the emerging era of genetic-based medicine, the research study, published today in the journal Nature, announces that scientists have determined the order of 33 million DNA bases, the chemical components of the genetic code, for nearly 700 genes on chromosome 22. Chromosome 22 is the first human chromosome to be sequenced under the federally sponsored Human Genome Project, which expects to complete a working draft of the sequences of all 23 human chromosomes by March of next year.

The multicenter study is co-authored by over 200 collaborators from research institutions in 6 nations. Among those collaborators is the research group from Children's Hospital, led by Beverly S. Emanuel, Ph.D. In 1995, Dr. Emanuel's laboratory completed an important earlier step in the process, publishing a physical map of chromosome 22. That map, one outcome of a five-year, $10 million federal grant, established the locations of genes and other DNA markers along the chromosome. It laid a foundation for today's far more detailed findings: the specific order of the nucleotides, the four chemical units that make up the DNA alphabet and which, in different combinations, form the chromosome's genetic code. In recognition of earlier pioneering genetics research on chromosome 22 by Dr. Emanuel and her colleagues, the National Institutes of Health desig

Contact: Kajsa Haracz
Children's Hospital of Philadelphia

Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:7/1/2020)... ... July 01, 2020 , ... ... and solutions for glioblastoma—the most common and aggressive adult brain cancer—announced today the ... PhD. Senior Fellows are charged with supporting the organization’s initiatives and overall vision. ...
(Date:6/23/2020)... ... June 23, 2020 , ... First ... Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable energy equipment, ... in the fight against the COVID-19 pandemic in Zambia. , One of Renovagen’s ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... “Automate Your Lab with Software for Data Decisions,” for pharmaceutical and biotech ... to integrate and automate cutting-edge scientific instruments and laboratory equipment from dozens ...
Breaking Biology News(10 mins):
(Date:6/19/2020)... ST. PETERSBURG, Russia (PRWEB) , ... June 18, 2020 , ... ... Fomenko in 2018. Its goal is to join forces to radically prolong life and ... and significantly postpone the aging period. This project was supported by various scientists from ...
(Date:6/11/2020)... ... June 09, 2020 , ... Reducing carbon emissions has been ... the Paris Agreement to stock market dips, ways to reduce CO2 is something we ... their portfolio. Most of the biofuels being produced today are created from recycled cooking ...
(Date:5/30/2020)... YORK (PRWEB) , ... May 29, 2020 , ... ... of Chief Medical Officer 360°, the first newsletter solely dedicated to the unique ... capture a wide range of perspectives on the responsibilities, problem-solving, best practices and ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... will cause long-term harm , Contrary to conventional wisdom that says the coronavirus ... finds many companies will emerge from the pandemic commercially weaker, dealing with delays ...
Breaking Biology Technology:
Cached News: