Researchers begin study to protect against anthrax

Scientists at the University of Rochester in Rochester, N.Y., and 11 other cities around the nation are beginning tests of an experimental vaccine aimed at protecting people against anthrax, a rare disease that, like smallpox, has become more threatening with the emergence of bioterrorism.

Doctors and nurses across the country hope to enroll a total of 480 people 40 people at each of 11 sites by the end of May in the study funded by the National Institute of Allergy and Infectious Diseases (NIAID).

For most of modern history anthrax has been a rare disease in people; it's most likely to infect farmers, veterinarians, and people who work with animals or animal products. That all changed more than two years ago, when several envelopes containing anthrax spores that bore the hallmark of sophisticated processing were mailed, emptying several office buildings, infecting several people, and spurring the search for a better vaccine.

While an anthrax vaccine now exists and is used primarily to protect military personnel, it requires a cumbersome routine six shots over 18 months, with a booster shot every year thereafter for the vaccine to confer protection. The current vaccine also causes a range of side effects.

Scientists are trying to develop a vaccine that works faster, with fewer shots and no annual booster, with fewer side effects. The vaccine under study, based on research by U.S. Army scientists and produced by California-based VaxGen Inc., requires two shots four weeks apart. Participants in the study will be monitored for one year as nurses and doctors record side effects and check the ability of the vaccine to rouse an immune response.

"If you're trying to immunize in the face of a threat, particularly if the infectious agent has already been released, a delay of 18 months until the vaccine is effective is a big problem," says John Treanor, M.D., professor of medicine and director of

Contact: Tom Rickey
University of Rochester Medical Center

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