HOME >> BIOLOGY >> NEWS
Researchers closer to defining function of two proteins involved in neurotransmitter release

DALLAS Researchers at UT Southwestern Medical Center at Dallas are a step closer to defining the function of two proteins involved in neurotransmitter release, which initiates communication between neurons in the brain.

Findings from the two-part study, published in todays issue of Nature, provides new insight in understanding how the brain functions, which ultimately has broad implications for the development of drug therapy to treat neurological diseases such as Alzheimers and Parkinsons, as well as learning and memory disorders.

This is pure, fundamental research, said Dr. Thomas Sdhof, director of the Center for Basic Neuroscience at UT Southwestern and senior author of the first part of the study. It is essential for understanding various diseases of the nervous system. The premise of our work is the understanding of neurotransmitter release, which is a necessity for understanding brain function and how the brain works.

The researchers bred mice that lacked the brain proteins RIM1a or Rab3A. In part one of the study, the researchers report a change in short-term plasticity in the mice lacking the RIM1α protein compared to other types of mutant mice. In part two of the study, the researchers report a correlation between the RIM1a protein and long-term plasticity. The terms short- and long-term plasticity refer to changes that occur during neurotransmitter release.

We found that the mice lacking the protein were still viable, but there were some deficits in short-term plasticity when changes occur at the synapses for a short period of time. The strength of synaptic transmission determines how we process information. It affects everything from memory to thinking and feeling, said Dr. Susanne Schoch, a postdoctoral research fellow and lead author of the two-part study.

We also found that RIM1a has a central function in neurotransmitter release and is required for long-term plasticity, which is similar to short-term
'"/>

Contact: Amy Shields
Amy.Shields@UTSouthwestern.edu
214-648-3404
UT Southwestern Medical Center
16-Jan-2002


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/29/2018)... (PRWEB) , ... July 29, 2018 , ... Dr. William ... biofield energy treated nutraceutical to improve overall immunity and to combat inflammation and autoimmune ... well as inflammation. The following data was reported:, Up ...
(Date:7/28/2018)... (PRWEB) , ... July 28, 2018 , ... ... at The Hong Kong Polytechnic University (PolyU), has been honoured with the International ... to the field of wind engineering and bridge engineering in research, education, and ...
(Date:7/26/2018)... ... July 25, 2018 , ... ... C-level biopharma executives on September 4, 2018 at The Hilton Boston Back Bay ... from real-life business development experiences and dissect the most relevant deals in biotech. ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... Wis. (PRWEB) , ... July 25, 2018 , ... ... of a biofield energy treated proprietary nutraceutical to combat inflammation and autoimmune disorders. ... well as, immune function response. The following data was reported:, ...
(Date:7/24/2018)... ... July 23, 2018 , ... Mark ... treated nutraceutical to increase immunity and improve anti-inflammatory, and immune function responses. , ... in the preclinical research were significantly reduced. Results are as follows:, ...
(Date:7/22/2018)... ... 2018 , ... Mitotech S.A, a Luxembourg based clinical stage ... clinical program in Dry Eye Disease. Under the agreement Essex Bio-Investment will fund ... the first Phase 3 study starting as early as Fall 2018. , ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... representations of a complex biological network, a depiction of a system of linkages ... said Dmitry Korkin, PhD, associate professor of computer science at Worcester Polytechnic Institute ...
Breaking Biology Technology:
Cached News: