HOME >> BIOLOGY >> NEWS
Researchers closer to defining function of two proteins involved in neurotransmitter release

DALLAS Researchers at UT Southwestern Medical Center at Dallas are a step closer to defining the function of two proteins involved in neurotransmitter release, which initiates communication between neurons in the brain.

Findings from the two-part study, published in todays issue of Nature, provides new insight in understanding how the brain functions, which ultimately has broad implications for the development of drug therapy to treat neurological diseases such as Alzheimers and Parkinsons, as well as learning and memory disorders.

This is pure, fundamental research, said Dr. Thomas Sdhof, director of the Center for Basic Neuroscience at UT Southwestern and senior author of the first part of the study. It is essential for understanding various diseases of the nervous system. The premise of our work is the understanding of neurotransmitter release, which is a necessity for understanding brain function and how the brain works.

The researchers bred mice that lacked the brain proteins RIM1a or Rab3A. In part one of the study, the researchers report a change in short-term plasticity in the mice lacking the RIM1α protein compared to other types of mutant mice. In part two of the study, the researchers report a correlation between the RIM1a protein and long-term plasticity. The terms short- and long-term plasticity refer to changes that occur during neurotransmitter release.

We found that the mice lacking the protein were still viable, but there were some deficits in short-term plasticity when changes occur at the synapses for a short period of time. The strength of synaptic transmission determines how we process information. It affects everything from memory to thinking and feeling, said Dr. Susanne Schoch, a postdoctoral research fellow and lead author of the two-part study.

We also found that RIM1a has a central function in neurotransmitter release and is required for long-term plasticity, which is similar to short-term
'"/>

Contact: Amy Shields
Amy.Shields@UTSouthwestern.edu
214-648-3404
UT Southwestern Medical Center
16-Jan-2002


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... KEY FINDINGS The global market ... CAGR of 25.76% during the forecast period of 2017-2025. ... for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is segmented ... The stem cell market of the product is segmented ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/29/2017)... CHICAGO , March 29, 2017  higi, the ... ecosystem in North America , today ... Partners and the acquisition of EveryMove. The new investment ... extensive set of tools to transform population health activities ... and lifestyle data. higi collects and secures ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... 2017  VMS BioMarketing, a leading provider of patient support ... Nurse Educator (CNE) network, which will launch this week. The ... health care professionals to enhance the patient care experience by ... other health care professionals to help women who have been ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator ... osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular STAT3 ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. spent ... entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, 2017 ... joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, Grossmont ...
Breaking Biology Technology:
Cached News: