HOME >> BIOLOGY >> NEWS
Researchers closer to defining function of two proteins involved in neurotransmitter release

DALLAS Researchers at UT Southwestern Medical Center at Dallas are a step closer to defining the function of two proteins involved in neurotransmitter release, which initiates communication between neurons in the brain.

Findings from the two-part study, published in todays issue of Nature, provides new insight in understanding how the brain functions, which ultimately has broad implications for the development of drug therapy to treat neurological diseases such as Alzheimers and Parkinsons, as well as learning and memory disorders.

This is pure, fundamental research, said Dr. Thomas Sdhof, director of the Center for Basic Neuroscience at UT Southwestern and senior author of the first part of the study. It is essential for understanding various diseases of the nervous system. The premise of our work is the understanding of neurotransmitter release, which is a necessity for understanding brain function and how the brain works.

The researchers bred mice that lacked the brain proteins RIM1a or Rab3A. In part one of the study, the researchers report a change in short-term plasticity in the mice lacking the RIM1α protein compared to other types of mutant mice. In part two of the study, the researchers report a correlation between the RIM1a protein and long-term plasticity. The terms short- and long-term plasticity refer to changes that occur during neurotransmitter release.

We found that the mice lacking the protein were still viable, but there were some deficits in short-term plasticity when changes occur at the synapses for a short period of time. The strength of synaptic transmission determines how we process information. It affects everything from memory to thinking and feeling, said Dr. Susanne Schoch, a postdoctoral research fellow and lead author of the two-part study.

We also found that RIM1a has a central function in neurotransmitter release and is required for long-term plasticity, which is similar to short-term
'"/>

Contact: Amy Shields
Amy.Shields@UTSouthwestern.edu
214-648-3404
UT Southwestern Medical Center
16-Jan-2002


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
(Date:8/31/2015)... , Aug. 31, 2015 Research and Markets ... "Saudi Arabia Biomedical Sensors Market - Growth, Trends ... The Saudi Arabia Biomedical Sensors market is ... of 3.64% over the period 2014-2020 The ... to the genetic formulation of each individual. These sensors ...
(Date:8/26/2015)... 2015 The report "Multi-Factor Authentication (MFA) ... Application (Travel & Immigration, Government, Banking, Defense, Commercial Security, ... 2020", published by MarketsandMarkets, Multi-Factor Authentication Market is expected ... a CAGR of 17.7% between 2015 and 2020. ... igures spread through 169 P ages ...
(Date:8/24/2015)... 24, 2015 The consulting company Frost ... biometrics manufacturer DERMALOG and its customized solutions and products for ... Company of the Year Award". DERMALOG is particularly successful with ...   -Cross reference: Picture is available at AP ... On Thursday evening, in South Africa,s ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3
(Date:9/3/2015)... Texas (PRWEB) , ... September 03, 2015 , ... ... suffered a hamstring tear 18 months ago. Conventional treatment and therapy were not ... in late June 2015. Dr. McKenna treated Zack with precisely guided injections ...
(Date:9/3/2015)... PUNE, India , September 3, 2015 ... "Chromatography Instruments Market by System (LC (HPLC, UHPLC, Flash), ... (Reverse Phase Columns, Syringe Filters, Vials) - Analysis & ... Instruments Market is expected to reach around 9.223 Billion ... a CAGR of 5.5%. Browse 141 tables ...
(Date:9/2/2015)... Sept. 2, 2015 Research and ... addition of Jain PharmaBiotech,s new report ... their offering. An increasing ... biotechnology industries is anticipated. Nanotechnology will be ... - from formulations for optimal delivery to ...
(Date:9/2/2015)... 2015 Research and ... of Jain PharmaBiotech,s new report "Biomarkers - ... This report follows the broad definition ... be objectively measured and evaluated as an indicator ... as pharmacological responses to a therapeutic intervention. Tests ...
Breaking Biology Technology:UCLA Wide Receiver and Canadian Decathlon Standout Zack Bornstein Bounces Back After Stem Cell Therapy at Riordan-McKenna Institute 2UCLA Wide Receiver and Canadian Decathlon Standout Zack Bornstein Bounces Back After Stem Cell Therapy at Riordan-McKenna Institute 3Chromatography Instruments Market Worth $ 9.223 Billion by 2020 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 3Chromatography Instruments Market Worth $ 9.223 Billion by 2020 4Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 2Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 3
Cached News: