HOME >> BIOLOGY >> NEWS
Researchers decipher chemical 'cross talk' that determines survival of immunecells

Molecular biologists at the University of California, San Francisco have deciphered a pattern of signals that spells life or death to each T cell of the immune system and may control the development of the body's natural defense arsenal.

When a virus, parasite or other pathogen invades a cell, the immune system's T cells recognize the enemy, and a potent chemical signal is triggered using a docking site known as the T cell receptor. The current research identifies a possible new role for this chemical message. The scientists suggest that the interplay between this signal and one produced by a hormone continually selects the T cell soldiers the body needs as it faces a changing cast of invaders. What controls this selection process has long puzzled biologists. The steroid hormone signal is normally present at low levels that fluctuate with daily rhythms, but stress can cause the hormone levels to spike. The new study may lead to a molecular understanding of how stress-induced hormone imbalance depresses immune system function, the scientists say. This imbalance sometimes leads the immune system to activate T cells that attack the body and cause autoimmune diseases.

The research was carried out to help clarify a larger question: how the cacophony of chemical messages streaming through a cell is ultimately "heard" as a single command to switch a gene on or off -- the fundamental unit of action in the cell.

"Signals from the environment, from hormones and many other sources are woven into a fabric," explains UCSF's Keith Yamamoto, PhD, professor and chair of molecular and cellular pharmacology. "It is the fabric that defines the state of the cell at any given time and determines whether or not genes are activated. We wanted to examine how different signals become integrated to produce instructions to the genetic machinery."

The scientists' findings are published in the June 20 issue of the Proceedings of the Nat
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
19-Jun-2000


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... ... September 17, 2019 , ... Dual-board certified periodontist ... the Australia Society of Implant Dentistry (ASID) Accreditation Courses. His lecture, “Understanding the ... Surgical Aspects of Modern Implant Dentistry course. Dr. Kim’s expertise comes from years ...
(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
(Date:8/29/2019)... CARLSBAD, Calif. (PRWEB) , ... ... ... daacro (Diagnostic Assessment and Clinical Research Organization), have recently passed ... combines CRO standards, hormone diagnostics and psychoneuroendocrine stress expertise, with a primary ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... September 09, 2019 , ... Tunnell ... government agencies, announced that its president and CEO Maryann Gallivan has been accepted ... , The Forbes Council accepted Gallivan based on the role she and ...
(Date:9/11/2019)... N.J. (PRWEB) , ... September 10, 2019 , ... ... development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, ... Forum, to be held at the Bausparkasse Schwäbisch Hall AG, Schwabisch Hall, Germany, ...
(Date:9/8/2019)... ... 2019 , ... Spartan Bioscience, the leader in on-demand DNA ... has been named Chief Financial Officer. , Spartan has also named former ... Additionally, Spartan has hired Steve Edgett as Executive Vice President to lead international ...
(Date:8/29/2019)... (PRWEB) , ... August 29, 2019 , ... ... chronic disease affecting grapevines, a feat they hope will ultimately help protect the ... Researchers including several Rochester Institute of Technology faculty and alumni sequenced the microbiome ...
Breaking Biology Technology:
Cached News: