HOME >> BIOLOGY >> NEWS
Researchers describe long-perplexing 'magic spot' on bacteria

COLUMBUS, Ohio Scientists have unraveled the behavior of one key component of bacteria, a finding that may lead to better, more effective antibiotics.

The researchers studied a mechanism of action they call the "magic spot" an important regulator of gene expression. They describe their results in the current issue of the journal Cell.

Researchers know that the magic spot a molecule known as guanosine-tetraphosphate or ppGpp is involved in how bacteria respond to amino acid starvation. More recently, researchers have discovered that ppGpp is an important part of pathogens that cause illnesses such as cholera and Legionnaires' disease.

A cell makes ppGpp when amino acid levels are low.

"Microbiologists have wondered for a half-century how this small molecule with a relatively simple structure could have such a profound effect on regulating a cell's survival," said Irina Artsimovitch, a study co-author and an assistant professor of microbiology at Ohio State University. She collaborated on this work with study lead author Dmitry Vassylyev, of the RIKEN Institute in Japan.

ppGpp controls what researchers call the "stringent response" a condition of nutritional starvation. When amino acid pools in a cell are exhausted, ppGpp accumulates and shuts down the synthesis of new proteins. The cell goes dormant until amino acid levels return to normal.

By learning the structure of ppGpp and how it interacts with the enzyme RNA polymerase the main enzyme that controls gene expression in a cell the researchers were able to describe in detail the "magic" behind the magic spot, Artsimovitch said.

"This study sheds a good deal of light on the inner workings of the molecular machinery that carries out gene expression in bacteria," she said. "Knowing this can serve as a basis for a new type of antibiotics.

In related work reported in a recent issue of the Journal of Bacteriology, Artsimovitch led a team of researche
'"/>

Contact: Irina Artsimovitch
Artsimovitch.1@osu.edu
614-292-6777
Ohio State University
29-Apr-2004


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/26/2016)... DUBLIN , April 27, 2016 ... of the  "Global Multi-modal Biometrics Market 2016-2020"  report ... ) , The analysts forecast ... a CAGR of 15.49% during the period 2016-2020.  ... a number of sectors such as the healthcare, ...
(Date:4/14/2016)... BioCatch ™, the global ... the appointment of Eyal Goldwerger as CEO. ... Goldwerger,s leadership appointment comes at a time of significant ... of its platform at several of the world,s largest ... unique cognitive and physiological factors, is a winner of ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, ... faculty of the University of North Carolina Kenan-Flagler Business School effective ... at UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks ... to industrial engineering, was today awarded as one ... selection of the world,s most innovative companies. Ginkgo ... scale for the real world in the nutrition, ... engineers work directly with customers including Fortune 500 ...
(Date:6/24/2016)... , June 24, 2016 Epic ... sensitively detects cancers susceptible to PARP inhibitors by ... tumor cells (CTCs). The new test has already ... therapeutics in multiple cancer types. Over ... DNA damage response pathways, including PARP, ATM, ATR, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita ... miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject of ... now. , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue ...
Breaking Biology Technology:
Cached News: