HOME >> BIOLOGY >> NEWS
Researchers describe long-perplexing 'magic spot' on bacteria

COLUMBUS, Ohio Scientists have unraveled the behavior of one key component of bacteria, a finding that may lead to better, more effective antibiotics.

The researchers studied a mechanism of action they call the "magic spot" an important regulator of gene expression. They describe their results in the current issue of the journal Cell.

Researchers know that the magic spot a molecule known as guanosine-tetraphosphate or ppGpp is involved in how bacteria respond to amino acid starvation. More recently, researchers have discovered that ppGpp is an important part of pathogens that cause illnesses such as cholera and Legionnaires' disease.

A cell makes ppGpp when amino acid levels are low.

"Microbiologists have wondered for a half-century how this small molecule with a relatively simple structure could have such a profound effect on regulating a cell's survival," said Irina Artsimovitch, a study co-author and an assistant professor of microbiology at Ohio State University. She collaborated on this work with study lead author Dmitry Vassylyev, of the RIKEN Institute in Japan.

ppGpp controls what researchers call the "stringent response" a condition of nutritional starvation. When amino acid pools in a cell are exhausted, ppGpp accumulates and shuts down the synthesis of new proteins. The cell goes dormant until amino acid levels return to normal.

By learning the structure of ppGpp and how it interacts with the enzyme RNA polymerase the main enzyme that controls gene expression in a cell the researchers were able to describe in detail the "magic" behind the magic spot, Artsimovitch said.

"This study sheds a good deal of light on the inner workings of the molecular machinery that carries out gene expression in bacteria," she said. "Knowing this can serve as a basis for a new type of antibiotics.

In related work reported in a recent issue of the Journal of Bacteriology, Artsimovitch led a team of researche
'"/>

Contact: Irina Artsimovitch
Artsimovitch.1@osu.edu
614-292-6777
Ohio State University
29-Apr-2004


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers describe long perplexing magic spot bacteria

(Date:7/25/2014)... girls reach puberty is influenced by ,imprinted genes,a subset of ... gene. This is the first evidence that imprinted genes ... of this study were published today in the journal ... menarche, is a marker for the timing of puberty in ... varies between girls, is an inherited trait, and is linked ...
(Date:7/25/2014)... time, Spanish researchers have detected an unknown interaction between ... are introduced into a droplet of salt water and ... crystallisation to create biomineralogical biosaline 3D morphologically complex formations, ... bacteria are revived. The discovery was made by chance ... of the Astrobiology journal and may help ...
(Date:7/24/2014)... wildlife loss leads to conflict among people around the ... Society (WCS) Health & Ecosystems: Analysis of Linkages (HEAL) ... approach to tackle global biodiversity decline. , The harvest ... world,s people and provides protein for more than a ... no surprise that today,s unprecedented loss of wildlife, is ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2Bacteria manipulate salt to build shelters to hibernate 2New study draws links between wildlife loss and social conflicts 2
(Date:7/24/2014)...  Now available is a stem cell therapy that ... , located in Guadalajara, Mexico , ... new health option: stem cell therapies for sports ... suffer from joint and muscle injuries due to professional ... rotator cuff, tennis elbow, and knee injuries. Throughout life ...
(Date:7/24/2014)... Security forces worldwide rely on sophisticated equipment, trained ... other public areas against terrorist attacks. A revolutionary ... about to make their job much easier. , ... Patolsky of Tel Aviv University ,s School of ... developed by the Herzliya company Tracense, picks up ...
(Date:7/24/2014)... Yan, Distinguished Professor of Engineering at the University ... to solve problems in energy engineering, environmental sustainability ... on zeolites, porous rock with a well-defined, crystalline ... is so precisely decided that zeolites can separate ... of an angstrom (one-tenth of a nanometer), making ...
(Date:7/24/2014)... -- Research and Markets has announced the ... Instruments Market 2014-2018" report to their offering. ... is the study of the gene and its functions ... functions of proteomes or sets of proteins by using ... the mapping of genes and DNA sequencing to understand ...
Breaking Biology Technology:Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2University of Delaware researcher describes new approach for creating organic zeolites 2Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2
Cached News: