HOME >> BIOLOGY >> NEWS
Researchers develop fast track way to discover how cells are regulated

SALT LAKE CITY, Sept. 17, 2004 -- Researchers at Huntsman Cancer Institute (HCI) at the University of Utah and a collaborator at the University of California at Santa Cruz report they have developed a unique computational approach to investigate a regulatory network for gene expression that is implicated in cell growth and development. The study was published today in the journal Science.

"When studying the genome of any organism, be it yeast, worm, fly or human, scientists are faced with a problem -- the incredible number of genes," explains Susan Mango, Ph.D., an HCI investigator and leader of the research team. Mango's research centered on a common garden-variety nematode worm, C. elegans, which shares many genes in common with humans. She explains that although worms appear simple, the worm genome is comprised of 20,000 genes. The human genome has over 30,000 genes. "When you look at the numbers, it becomes very clear that the old way -- studying one gene at a time -- is too slow. It becomes a problem of scale, with high throughput the only answer."

Mango's team used a unique process that combines microarray technology with computational approaches to predict, based on probabilities, where in the genome a particular regulatory sequence might be found. With co-authors Wanyuan Ao, Ph.D.; Jeb Gaudet, Ph.D.; James Kent, Ph.D.; and Srikanth Mattumu, Mango searched C. elegans's genome to find certain "punctuation marks" in the code that might be regulatory sequences responsible for the growth and development of the worm's foregut, or pharynx. They were able to identify a total of seven candidate gene sequences; after testing, they discovered that of the seven, five proved to be bona fide regulatory sequences.

"Up to now, identifying transcription factor target genes has been a challenge to biologists. Using our unique algorithm, the Improbizer algorithm developed by James Kent, one of our collaborators, we were able to pick out regulatory s
'"/>


17-Sep-2004


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers identify distinctive signature for metastatic prostate cancer
8. Researchers report new gene test for isolated cleft lip and palate
9. Researchers discover why mutant gene causes colon cancer
10. Researchers identify the genomes controlling elements
11. Researchers improve detection of diverse anthrax strains

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/21/2019)... (PRWEB) , ... December 20, 2019 , ... The City ... Convention and SAGICO was on hand to honor these heroes. Tampa welcomed these most-highly ... leaders, veteran organizations and community leaders honored these distinguished service members. , The Medal ...
(Date:12/14/2019)... ... December 10, 2019 , ... A study by researchers ... food are able to reduce the virulence of, and even prevent infections by, ... immune-compromised individuals, including the multi-drug resistant Candida auris, which was recently listed as ...
(Date:12/4/2019)... , ... December 04, 2019 , ... ... Dr. Marque Todd , a regulatory toxicology expert with more than 20 ... an Expert Consultant. , Dr. Todd has extensive experience with a variety ...
Breaking Biology News(10 mins):
(Date:1/7/2020)... Conn. (PRWEB) , ... January 06, 2020 , ... ... today announced the second cohort of emerging biosciences ventures invited to participate in ... business education to develop fundable business plans and a professional network. All startups ...
(Date:12/30/2019)... ... December 30, 2019 , ... Leak Detection Associates (LDA), ... Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries is pleased to announce the ... program specific to the custom-built helium leak testing systems it designs and manufactures. ...
(Date:12/23/2019)... (PRWEB) , ... December 23, 2019 , ... ... leak detection systems for the Pharmaceutical, Biotechnology and Medical Device Industries, is excited ... at the Parenteral Drug Association (PDA) Container Closure Integrity Testing Basic Training ...
(Date:12/18/2019)... ... December 18, 2019 , ... Tune in to CNBC on ... Ted Danson. Check local listings for more information on this program. , With a ... are helping to simplify complex system to increase the efficiency, safety and effectiveness of ...
Breaking Biology Technology:
Cached News: