HOME >> BIOLOGY >> NEWS
Researchers develop new technique for identifying remaining unknown human genes

Scientists from the University of Chicago and Johns Hopkins University have developed a new technique that promises to significantly enhance the rate of novel-gene discovery, a process that becomes increasingly difficult as the Human Genome Project moves closer to completion.

"We have identified and corrected a fundamental flaw in the current genomewide gene studies," note the authors in the April 11 issue of the Proceedings of the National Academy of Sciences. The technique they developed "provides a much higher degree of novel gene identification than the current approaches," adds lead author San Ming Wang, Ph.D., assistant professor of medicine at the University of Chicago.

Although two thirds, more than 90,000, of the estimated 140,000 human genes have already been identified, finding the final third could be far more challenging. These elusive, as yet undiscovered genes tend to be expressed at low levels or only in certain cell types, or turned on only during specific developmental stages or growth conditions. Yet these genes may play important roles in normal processes or in the development or prevention of various diseases.

To speed the search for these unknown genes, scientists use a "subtraction" method to remove the bulk of ubiquitous, already-identified genes from a sample pool of genetic material, leaving behind a higher percentage of the undiscovered genes expressed less frequently or at low levels in an attempt to increase the probability of discovering these genes.

However, this subtraction method often results in a nightmare; many of these unknown genes disappear after this treatment. The authors have figured out how and why this occurs.

Genes are located in DNA. They are expressed as messenger RNA from which protein is made. This messenger RNA is the target for gene discovery.

In order to identify genes, the messenger RNA needs to be converted back into DNA molecules called complementary DNA. The subtraction met
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773-702-6241
University of Chicago Medical Center
10-Apr-2000


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ROTTERDAM, the Netherlands and LAGUNA HILLS, ... that The Institute of Cancer Research, London ... will use MMprofilerâ„¢ with SKY92, SkylineDx,s prognostic tool to risk-stratify ... high-risk trial known as MUK nine . The University ... this trial, which is partly funded by Myeloma UK, and ...
(Date:10/10/2017)... ... , ... San Diego-based team building and cooking events company, Lajollacooks4u, has unveiled ... bold new look is part of a transformation to increase awareness, appeal to new ... , It will also expand its service offering from its signature gourmet cooking classes ...
(Date:10/10/2017)... International research firm Parks Associates announced today that Tom ... 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and ...
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology:
Cached News: