HOME >> BIOLOGY >> NEWS
Researchers develop novel mouse model of Alzheimer's disease

An obstacle to understanding how Alzheimer's disease develops has been the lack of an accurate animal model for scientific study. Now, scientists in Cleveland report that they have developed novel genetically engineered mice that exhibit pathological characteristics of Alzheimer's disease. These mice will likely provide new insights into the disease and its treatment.

In work to be published in the August issue of the journal Nature Neuroscience, Bruce Lamb, assistant professor of genetics, and colleagues at Case Western Reserve University's School of Medicine and University Hospitals of Cleveland created the lines of mice using yeast artificial chromosomes to transfer pieces of human DNA into mice. The researchers incorporated into the mice entire copies of human genes that result in early-onset Alzheimer's disease in humans.

One gene encodes amyloid precursor protein (APP), the protein that gives rise to the characteristic amyloid deposits (beta-amyloid proteins) that occur in the brains of Alzheimer's disease patients. The other gene encodes presenilin-1 (PS-1), a protein that has been implicated in the biochemical processing of APP.

The researchers found that mice carrying the mutant form of APP developed amyloid deposits similar to those found in patients with Alzheimer's disease. Moreover, mice with two copies of the APP gene, or with both mutant genes, developed even more deposits.

"Higher levels of beta-amyloid protein are vital for the appearance of Alzheimer's disease pathology in mice, similar to what has been observed in humans with the genetic forms of the disease," said Lamb, who is also affiliated with the University Alzheimer Center in Cleveland. "In addition, further elevation of the levels of beta-amyloid accelerates the age of onset of pathological changes observed in the mice."

He said that additional experiments will be necessary to determine the relationship between the pathology observed in these transgenic mice and
'"/>

Contact: George Stamatis
gxs18@po.cwru.edu
216-368-3635
Case Western Reserve University
20-Jul-1999


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/27/2019)... ... November 26, 2019 , ... Personalized Stem Cells, Inc (“PSC”), a ... Foundation and hosted by Dr. Steven Sampson and Dr. Danielle Aufiero of the ... 23, 2019, highlighted the ongoing efforts to promote research, educate the public, and provide ...
(Date:11/22/2019)... ... November 21, 2019 , ... The inventors of ... have announced a major step forward with that therapy, known as SurVaxM. MimiVax ... company, spun off from Roswell Park in 2012, has entered into a China-exclusive ...
(Date:11/19/2019)... ... ... Project Lifeline – a community partnership and research program initiated ... use disorder (SUD) – will take center stage at the upcoming NACDS ... in preventing and treating opioid abuse in Blair County, Pennsylvania, will receive the NACDS ...
Breaking Biology News(10 mins):
(Date:10/30/2019)... ... October 30, 2019 , ... ... the many roles innovation and technology play in educating the next generation of ... hands-on learning opportunities and presentations by WesternU administrators and representatives of companies working ...
(Date:10/29/2019)... ... October 29, 2019 , ... Researchers ... Using Silios CMS-C multispectral imagers , researchers identified people by the image ... based on retinal imaging, face recognition, fingerprints and vasculature. , The new ...
(Date:10/22/2019)... ... October 22, 2019 , ... Catalent, a global leader in clinical supply services, ... Integration, will participate in a panel session titled “Cell and Gene Therapy Logistics” at ... Gwen Hotel, Chicago, on Oct. 28-30, 2019. , The panel session, on Wednesday, Oct. ...
(Date:10/17/2019)... PARK, Kan. (PRWEB) , ... October 15, 2019 ... ... to 23andMe, a leader among services that offer DNA Testing for health and/or ... so popular. Everywhere you look, it seems that people want to know more ...
Breaking Biology Technology:
Cached News: