HOME >> BIOLOGY >> NEWS
Researchers discover hemoglobin's enzymatic nature

September 30, 1999--The nematode worm Ascaris lumbricoides, an intestinal parasite that infects one billion people worldwide, has uncommonly strong hemoglobin that binds to oxygen 25,000-times more tightly than does human hemoglobin. The affinity of Ascaris hemoglobin for oxygen is so powerful that many researchers believed the molecule could not possibly play a role in respiration.

Learning the true function of Ascaris hemoglobin and understanding how and why the worm's hemoglobin embraces oxygen molecules so tightly have been great challenges, said Howard Hughes Medical Institute (HHMI) investigator Jonathan Stamler. "Why would a molecule that functions as an oxygen carrier bind oxygen so tightly that the oxygen molecules would never come off?"

Two collaborating groups of HHMI scientists have ferreted out the secrets of this oxygen-hungry molecule by using a variety of biochemical techniques and by taking physical measurements of the hemoglobin inside the worm. In so doing, they have identified a biochemical link between the hemoglobins used by primordial bacteria to detoxify themselves of atmospheric gases and the modern mammalian hemoglobins that underpin respiration.

The findings not only open a window to understanding how a wide variety of organisms evolved to utilize or guard against atmospheric gases such as oxygen and nitric oxide, but they may also provide new ideas for ways to starve cancerous tumors of oxygen.

In the September 30, 1999, issue of the journal Nature, research groups led by Stamler, an HHMI investigator at Duke University, and Daniel Goldberg, an HHMI investigator at Washington University in St. Louis, describe how Ascaris hemoglobin acts as an enzyme to neutralize oxygen, which in high doses is toxic to the worm.

"In humans, hemog
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
30-Sep-1999


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
(Date:4/19/2017)... , April 19, 2017 The ... vendor landscape is marked by the presence of several ... however held by five major players - 3M Cogent, ... companies accounted for nearly 61% of the global military ... companies in the global military biometrics market boast global ...
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... NJ (PRWEB) , ... October 11, 2017 , ... Personal eye wash is a basic ... one eye at a time. So which eye do you rinse first if a dangerous ... have Plum Duo Eye Wash with its unique dual eye piece. , “Whether ...
(Date:10/11/2017)... ROTTERDAM, the Netherlands and LAGUNA HILLS, ... that The Institute of Cancer Research, London ... will use MMprofilerâ„¢ with SKY92, SkylineDx,s prognostic tool to risk-stratify ... high-risk trial known as MUK nine . The University ... this trial, which is partly funded by Myeloma UK, and ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... San Diego-based ... of its corporate rebranding initiative announced today. The bold new look is part ... as the company moves into a significant growth period. , It will also expand ...
(Date:10/10/2017)... Oct. 10, 2017 International research firm Parks Associates ... speak at the TMA 2017 Annual Meeting , October 11 in ... the residential home security market and how smart safety and security products ... Parks Associates: Smart ... "The residential security market ...
Breaking Biology Technology:
Cached News: