Researchers discover how immune system rids nervous system of mosquito-borne viruses

Researchers at the Johns Hopkins Bloomberg School of Public Health have determined that neurons in the central nervous system react differently to the bodys immune defenses to rid themselves of viruses that cause encephalitis, such as West Nile and Eastern Equine Encephalitis viruses. Encephalitis is an inflammation of the brain and can cause neurological problems including, seizures, coma, and death.

In a study published in the July 13, 2001 issue of Science, researchers discovered that T-cells produce a protein, interferon-g, which can clear the virus in neurons located in the spinal cord and brain stem, but not in neurons located in the cerebral cortex. Neurons are cells that conduct and generate electrical impulses to carry information throughout the central nervous system. The findings add to the understanding of lymphocytes in the immune system and interactions of the central nervous system and could lead to new approaches to the treatment of viral encephalitis.

Our previous research indicated that antibodies successfully clear infection from the central nervous system. With this study, we wanted to see if lymphocytes could also clear viral infections from the neurons, says Diane Griffin, MD, PhD, professor and chair of the W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. Normally, T-cells control virus infections by destroying infected cells, but that would be counterproductive for neurons, because the body does not make new neurons, explains Dr. Griffin.

For the study, the researchers observed mice that did not have the ability to produce antibodies and compared them to normal mice. The mice were infected with Sindbis virus, a mosquito-borne virus related to other causes of encephalitis transmitted by mosquitoes, such as West Nile and Eastern Equine encephalitis viruses.

During the experiments, Gwendolyn Binder, a graduate student in the laborato

Contact: Tim Parsons or Ming Tai
Johns Hopkins University Bloomberg School of Public Health

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