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Researchers discover location of a testicular cancer gene

ncer by three weeks of age, demonstrating a strong testicular cancer susceptibility gene is located on Chromosome 19. (The corresponding gene in humans is located on chromosome segment 10q26.)

"The cancer results from a combination of genes in the host background and a gene on the substituted chromosome from the other strain," said Nadeau. "Most common human diseases have similar genetics, but are exceedingly hard to study because of the inherent complexity."

He added, "Chromosome substitution is a new and powerful way to simplify the analysis of many kinds of highly complex traits."

For Nadeau and colleagues, the search is now to discover the identity of this important new testicular cancer susceptibility gene. This new strain with its high frequency of testicular cancer is also the long-sought model for understanding the basis for the extraordinary response of testicular cancer to chemotherapies. These discoveries may lead to improved treatments of testicular and other cancers.


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Contact: George Stamatis
gxs18@po.cwru.edu
216-368-3635
Case Western Reserve University
1-Oct-1999


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