Researchers discover molecular 'switch' that tells body to store or burn fat

An enzyme called SCD-1 plays a crucial role through the hormone leptin in signaling the body to either store fat or burn it, report a team of scientists in the July 12 issue of the journal Science.

The researchers, led by Jeffrey M. Friedman, M.D., Ph.D., a Howard Hughes Medical Institute investigator at The Rockefeller University, and James M. Ntambi, Ph.D., at the University of Wisconsin at Madison, showed that obese (ob/ob) mice, which lack the hormone leptin, lost weight by burning calories, when genetically crossed with a strain of mice carrying a mutation in SCD-1.

The missing SCD-1 enzyme also corrects a major clinical problem called fatty liver, which is found in leptin-deficient mice and several clinical settings in humans. These new findings point to a potentially novel strategy for treating obesity and fatty liver and add important new information concerning the mechanism by which leptin regulates body weight and metabolism.

Obese, leptin-deficient mice with mutations in SCD-1 lost weight despite continuing to overeat.

"Leptin causes weight loss by reducing food intake and by increasing energy expenditure. It is both surprising and important that a deficiency of SCD-1 reduced obesity by increasing energy expenditure without affecting food intake at all," says first author Paul Cohen, graduate student in the joint Tri-institutional M.D.-Ph.D. Program of Rockefeller, Weill Medical College of Cornell University and Sloan-Kettering Institute.

"SCD-1 appears to be an important control point and may function as a switch determining whether fat is stored or burned," adds Friedman, professor and head of laboratory at Rockefeller.

Leptin and SCD-1 are members of a complex metabolic pathway that governs the body's propensity to burn fat. The ob gene, which codes for leptin, was isolated in 1994 by Friedman's HHMI laboratory at Rockefeller. Leptin, named after the Greek root "leptos" meaning thin, was subsequently

Contact: Joseph Bonner
Rockefeller University

Page: 1 2 3 4 5 6

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:8/14/2018)... ... August 13, 2018 , ... NRD, LLC – NRD® is ... Ionizing Gun. , The ionizing gun features ergonomic design and rugged construction. ... filter and electropolished OSHA-compliant tip. This can be cleanroom packaged (P-2021-5502) or normally ...
(Date:8/14/2018)... ... August 14, 2018 , ... From ... movie “Wonder,” to a better understanding of congenital heart defects, 3-D printing is ... the latest special issue of Birth Defects Research (DOI: 10.1002/bdr2.1367). ...
(Date:8/7/2018)... ... 06, 2018 , ... Nurse practitioners and ... their healthcare careers in the past year, according to the second annual survey ... jobseekers with a wide variety of career- and employment-related resources including physician/candidate database, ...
Breaking Biology News(10 mins):
(Date:7/24/2018)... ... ... R3 Stem Cell is now offering regenerative therapies for COPD lung disease ... Certified providers, with outcomes significantly improving patient quality of life. , Traditional therapies for ... help repair and regenerate damaged lung tissues. Stem cell therapy for COPD ...
(Date:7/24/2018)... ... 24, 2018 , ... On August 6, 2018, BioMedGPS will ... Not just a pretty face, SmartTRAK 3.0’s latest improvements were inspired by its ... world’s first online and real-time data portal that specializes in providing competitive market ...
(Date:7/22/2018)... ... July 19, 2018 , ... Mitotech ... with Essex Bio-Investment for Phase 3 clinical program in Dry Eye Disease. Under ... SkQ1 with approximately $17m allocated towards the first Phase 3 study starting as ...
(Date:7/22/2018)... ... July 20, 2018 , ... ... automation and IT solutions with 150 employees on both the east and west ... Program. Superior Controls met the high criteria for application expertise, operational excellence ...
Breaking Biology Technology:
Cached News: