HOME >> BIOLOGY >> NEWS
Researchers discover new mechanism that targets and destroys abnormal RNA

March 22, 2002 -- Research teams from two Howard Hughes Medical Institute (HHMI) laboratories have identified a new mechanism that cells use to recognize and destroy abnormal messenger RNA (mRNA). It is likely that cells employ the new mechanism, called nonstop decay, to target and destroy RNA molecules that contain errors.

Although nonstop decay is a normal RNA-policing mechanism, the researchers suggest that it might interfere with some drug treatments for cystic fibrosis and other genetic diseases. The new studies suggest that nonstop decay can be thwarted, which may make drug treatments for these diseases more effective.

The discovery of nonstop decay is reported in the March 22, 2002, issue of the journal Science by research teams led by HHMI investigators Harry C. Dietzat The Johns Hopkins University School of Medicine, and Roy R. Parker at the University of Arizona.

Messenger RNA molecules are the genetic templates for proteins. In constructing proteins, the mRNA template is transcribed from DNA genes and transported to the ribosomes the cells protein factories that are large complexes of protein and RNA. Given the importance of mRNA as an information-carrying molecule, the machinery that regulates mRNA levels and destroys faulty mRNA is critical in ensuring that errors in the genetic code are not passed on to proteins.

According to Dietz, his research team first believed that nonstop decay was similar to nonsense-mediated decay, the cells principal mechanism for destroying faulty mRNA that contains abnormal early stop signals called nonsense codons. Many genetic mutations or errors in transcribing mRNA result in nonsense codons that fail to code for any amino acids, the building blocks of proteins.

At the beginning, we had the hypothesis that an mRNA nonstop trans
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
21-Mar-2002


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/27/2020)... SAN DIEGO (PRWEB) , ... January 27, 2020 ... ... Christopher Thorne as Chairman. Thorne is a noted investor, tech entrepreneur, and former ... serves as Executive Chairman of Broadline Capital, the global alternative investment firm. ...
(Date:1/24/2020)... ... January 24, 2020 , ... The ... Colorado’s capital resources to support early-stage bioscience companies in the state. ... struggled to find the funding they need to innovate and grow. This ...
(Date:1/23/2020)... ATLANTA (PRWEB) , ... January 23, 2020 , ... ... to manufacture lifesaving mature red blood cells from stem cells. The red ... red blood cells, under strictly controlled conditions, for transfusion therapy and replaces the ...
Breaking Biology News(10 mins):
(Date:2/19/2020)... , ... February 18, 2020 , ... ... devices, today announced the launch of a new and unified global brand identity, ... the industry’s most complex engineering challenges, as well as an enthusiasm for designing ...
(Date:2/11/2020)... ... February 11, 2020 , ... Synagro Technologies, ... America, today announced that the City of Fort Worth has partnered with Synagro ... Commencing in April of 2020, Synagro will assume operation of the city’s current ...
(Date:2/3/2020)... ... February 03, 2020 , ... Ovation Travel ... Firm Travel, Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. , All of ... the following statistics:, Average airfare price paid Domestically, ...
(Date:1/28/2020)... STATE COLLEGE, Pa. (PRWEB) , ... January 28, ... ... trusted line of Better Salivary Assay Kits . The new Salivary ... salivary bioscience research. “By measuring total immunoglobulin G in saliva, researchers can extend ...
Breaking Biology Technology:
Cached News: