HOME >> BIOLOGY >> NEWS
Researchers discover new risk factor for colon cancer

A combination of mouse and human studies have revealed that people who are carriers of the rare disease Bloom syndrome are at increased risk for developing colorectal cancer.

In two studies, published in the September 20, 2002, issue of the journal Science, collaborative teams of scientists present evidence that a mutation in one of two copies of the Bloom syndrome gene (BLM) is sufficient to raise the risk of cancer in mice and humans. The results are the first to show that being a carrier of a recessive cancer syndrome gene can raise the risk of cancer, even if that individual does not have the disease itself.

"The findings remind us that knowing your family history of disease is very important," said Howard Hughes Medical Institute investigator Joanna Groden, who led the team that conducted the experiments in mice. "Even cancers that we think of as common and age-related can have a hereditary component."

In the case of Bloom syndrome, people who have two defective copies of the BLM gene are generally of short stature and have a variety of physical defects and a predisposition to developing many types of cancer. Bloom syndrome occurs in all ethnic populations, but it is more common in Jewish people of European descent (Ashkenazi Jews).

The BLM protein plays a role in helping ensure that chromosomes are copied properly during cell division. When the BLM protein is defective or missing, cells are more likely to acquire or keep DNA-copying errors that result in mutation. The chromosomes in cells without BLM also may have trouble getting untangled during cell division, sometimes causing pieces of chromosomes to break off.

Groden and her colleagues at the University of Cincinnati conducted a series of experiments in mice that were engineered to carry a single copy of the mutant Blm gene. These mice, which also had one normal copy of the
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
19-Sep-2002


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... 2018 , ... EDETEK, the premier provider of digital clinical trial platforms, today ... MD on October 8-12, 2018. EDETEK is also a Gold Sponsor of the Bay-area ... , CDISC Interchanges are global events held annually on three continents with hundreds of ...
(Date:10/5/2018)... ... October 04, 2018 , ... Nothing brings a team together like ... popular. , Cooking appeals to companies because it encourages a range of ... collaboration and decision-making skills. It’s also appealing in that everyone – no matter ...
(Date:10/3/2018)... ... October 03, 2018 , ... ... commercialization of first-in-class stromal cell immunotherapies, announced that ORBCEL-M™, a second generation ... diabetes and progressive diabetic kidney disease in a four-site, pan-European Phase I/II ...
Breaking Biology News(10 mins):
(Date:10/5/2018)... (PRWEB) , ... October 04, 2018 , ... ... an Anacortes, Wash.-based nonprofit, with a grant to purchase a high-tech machine that ... that washes ashore in Washington State. The organization then processes the usable plastic ...
(Date:10/2/2018)... ... October 02, 2018 , ... Finalists ... LLC’s (Locus Bio-Energy) AssurEOR product line was chosen for its advancements in the ... Information, honor leading innovations in upstream oil applications that are positively impacting the ...
(Date:9/28/2018)... , ... September 28, 2018 , ... ... (PMLS) to increase the availability of the GlycoMark test, the only FDA-cleared blood ... With the partnership, PMLS will promote and offer the GlycoMark test to its ...
(Date:9/27/2018)... (PRWEB) , ... September 26, 2018 , ... ... Medable is a platform that aims to build the first human digitome, a ... trial and real-world data through a seamless integration of all data sources. Dr. ...
Breaking Biology Technology:
Cached News: