Researchers establish first molecular link between eating and aging

Forget the drastic reduction in carbs and calories called for by diet dictators. The day when people can eat their favorite foods, stay thin and live to be 120 without getting age-induced diabetes or cancer may be nearer than we think. Researchers at MIT believe they've found the key to a long, lean, healthy life in a single protein that controls whether a mammal stores fat or sheds it. The work could lead to drugs that mimic that protein, allowing human beings to get the longer lifespan and other benefits of extreme caloric reduction without the negative side effects, said MIT Professor of Biology Leonard Guarente.

Guarente and other scientists have known for decades that controlled famine can extend the lifespan of mammals by as much as 50 percent and that those long-lived, lean mammals don't get the diseases of old age.

But just how a vastly reduced caloric intake achieves that feat has been a mystery begging for a solution--until now.

"For the first time, this study gives us a glimpse of how calorie restriction works at the molecular level. And it will ultimately lead to health benefits in people," said Guarente, who has been studying the aging process in yeast, roundworms and mice for more than a decade.

In the June 2 online issue of the journal Nature, scientists in Guarente's lab, including Frdric Picard, a research scientist in the Department of Biology who is lead author of the paper, publish their research results about how the Sirt1 mammalian gene promotes fat mobilization in mice.

A mammal generally burns the protein and carbohydrates in its food immediately; it stores fat in special cells called white adipose tissue (WAT). When it reduces its caloric intake, the WAT stops storing fat and begins releasing it for metabolism.

The paper's authors learned that fat is released from or metabolized by the body, rather than stored, when the Sirt1 protein senses short-term famine and turns off the receptors that

Contact: Denise Brehm
Massachusetts Institute of Technology

Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:5/28/2020)... ... 27, 2020 , ... CrucialTrak, a global designer and manufacturer of biometric access ... (CEG) to market and sell its complete line of biometric readers and access ... infrastructure optimization solutions . , Brett Mason, CrucialTrak’s Director of Channel Sales for ...
(Date:5/28/2020)... ... May 28, 2020 , ... Actuate Therapeutics, ... their 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) will be presented at ... place virtually on May 29th, 2020. Dr. Benedito Carneiro, Brown University’s principal investigator ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... background and medical screening, announces the launch of a testing service aimed ... safe. The new service is provided by ClearStar’s Medical Information Services (“MIS”) ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... 23, 2020 , ... Kerafast Inc. , developers of ... the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. The system, ... SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level 2 (BSL-2) ...
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen Pharmaceuticals Inc., announced today ... 22-24 during the American Association for Cancer Research Virtual meeting. One poster describes ... consistent single agent activity in KEAP1 mutant tumor models of NSCLC. ...
(Date:6/11/2020)... ... , ... Greffex, a leading genetic engineering company, with the ... vectors, recently announced a key manufacturing agreement with FUJIFILM Diosynth Biotechnologies to produce ... successful gene therapy delivery vehicle (vector) with broad applications for delivering treatments including ...
(Date:6/11/2020)... ... 2020 , ... Reducing carbon emissions has been and will continue to be ... market dips, ways to reduce CO2 is something we can’t avoid. , To ... biofuels being produced today are created from recycled cooking oil or crops. Unfortunately, these ...
Breaking Biology Technology:
Cached News: