HOME >> BIOLOGY >> NEWS
Researchers find a genetic connection in Sudden Infant Death Syndrome (SIDS)

d.

The results suggest an association between SIDS and the 5-HTT gene. "There was a significant difference in genotype distribution and an increased frequency of the L allele in SIDS cases versus ethnicity/gender matched controls with no family history of SIDS or autonomic dysfunction," the authors report. "Furthermore, there were significantly fewer SIDS cases versus controls with no long allele (S/S genotype) in the entire cohort and within the Caucasian subgroup; and significantly more SIDS cases versus controls with no short allele (L/L genotype) in the entire cohort."

The researchers also found that genotype frequency distributions and allele frequency distributions for 5-HTT were significantly different when evaluated across all ethnic groups. Despite ethnic variations, however, SIDS cases were more likely than controls to have the long allele in the Japanese, Caucasian, and African American study samples.

The study's results are compelling, though limited by the research design that included only confirmed anonymous SIDS cases from the NIH-supported University of Maryland Brain Bank, according to Dr. Weese-Mayer. Further studies should encompass larger numbers and more ethnicities and also include the 5-HTT intron 2 VTNR which influences gene expression. Likewise, Dr. Weese-Mayer et al pointed out that "recognizing the strong relationship between tobacco exposure (prenatal and postnatal) and SIDS risk, future studies of genetic polymorphisms must also include detailed smoking history to clarify the role of gene-environment interaction."

"If a larger data set reflects observations similar to those in this report," the authors conclude, "the serotonergic system will represent a key area for further investigation into the causal basis for SIDS, with the goal of identifying genetic risk factors that will aide in recognizing at-risk individuals who require specialized intervention strategies and in counseling families as to the risk of
'"/>

Contact: John M. Pontarelli
jpontare@rush.edu
312-942-5949
Rush University Medical Center
17-Jan-2003


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/20/2016)... , Dec. 20, 2016 The rising ... rental and leasing is stoking significant interest in ... frequency technology, Bluetooth low energy (BLE), biometrics and ... the next wave of wireless technologies in the ... system to advanced access systems opens the market ...
(Date:12/16/2016)... 2016   IdentyTechSolutions America LLC , a ... solutions and a cutting-edge manufacturer of software and ... offering seamless, integrated solutions that comprise IDT biometric ... solutions provide IdentyTech,s customers with combined physical identification ... crime and theft. "We are proud ...
(Date:12/15/2016)... Germany , December 15, 2016 ... announced an agreement with NuData Security, an award-winning ... partnership will enable clients to focus on good customer experience, ... protection regulation. ... In order to provide a one-stop fraud prevention suite, ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... , ... January 19, 2017 ... ... advanced software solutions for pharmaceutical research and development (R&D), today announced the ... omic data analysis and interpretation for the rapidly evolving field of precision ...
(Date:1/19/2017)... ... January 18, 2017 , ... The American Medical Informatics Association ... Data Sharing Policy. Specifically, the nation’s leading informatics experts, said data sharing plans ... policy. AMIA recommended that NIH earmark funding for researchers to produce and execute ...
(Date:1/19/2017)... Md. , Jan. 18, 2017  Northwest Biotherapeutics, ... developing DCVax® personalized immune therapies for operable and inoperable ... Bosch , Chief Technical Officer of NW Bio, will ... January 19, 2017, at the Hyatt Regency Hotel in ... Bosch will chair the session entitled "New Therapeutic Approaches ...
(Date:1/18/2017)... --  Boston Biomedical , an industry leader in the ... pathways, will feature data from two clinical studies for ... Gastrointestinal Cancers Symposium, held from January 19-21, in ... is an orally-administered investigational agent designed to inhibit cancer ... cells (CSCs) possess the property of stemness – the ...
Breaking Biology Technology:
Cached News: