HOME >> BIOLOGY >> NEWS
Researchers find an association between alcohol dependence and the GABAA receptor gene GABRG3

  • Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter in the human central nervous system.
  • Previous research has suggested the involvement of GABAA receptor genes in alcohol use and abuse.
  • New research has found that one GABAA receptor gene in particular, GABRG3, has a consistent association with alcohol dependence.

Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter in the human central nervous system. Previous research has suggested that GABA is involved in many of the neurochemical pathways affecting alcohol use, abuse and dependence. A study in the January issue of Alcoholism: Clinical & Experimental Research, using family-based analyses to examine the role of a cluster of GABAA receptor genes on chromosome 15q, becomes one of the first to demonstrate a consistent association between alcohol dependence and GABAA receptor gene GABRG3.

"There are several lines of evidence that suggest that GABA is involved in alcohol use and abuse," explained Danielle M. Dick, assistant professor in the department of psychiatry at Washington University School of Medicine and first author of the study. "For example, chemicals that increase the activity of GABAA receptors tend to accentuate the behavioral effects of alcohol, such as motor incoordination, sedation, and withdrawal signs, while chemicals that block GABAA receptors lessen these effects."

For this study, Dick and her colleagues decided to focus on GABAA receptor genes on chromosome 15q because of earlier findings from the multi-site Collaborative Study on the Genetics of Alcoholism (COGA) "suggesting a gene influencing alcoholism-related phenotypes in this area," she said.

Tapping into the COGA data once again, researchers tested for an association between alcohol dependence and three chromosome 15q GABAA receptor genes GABRA5, GABRB3, and GABRG3 in 2,282 individuals from 262 alcoholic families.
'"/>


14-Jan-2004


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/12/2017)... PUNE, India , January 12, 2017 A new ... - 2022," projects that the global biometric technology market is expected to generate revenue ... 2022. Continue Reading ... ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) ...
(Date:1/11/2017)... , Jan. 11, 2017  Michael Johnson, co-founder of Visikol ... Capital Group, Inc., has been named to the elite "Forbes 30 ...  was one of 600 people in 20 fields nationwide to be ... of the 15,000 applicants were selected. ... He is currently a PhD candidate at Rutgers ...
(Date:1/6/2017)... 2017  SomaLogic announced today that it has ... by iCarbonX, the China -based ... Digital Health Ecosystem that can define each person,s ... biological, behavioral and psychological data, the Internet and ... SomaLogic will provide proteomics data and applications expertise ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... ... January 18, 2017 , ... ... bio-focused Manufacturing Innovation Institutes (MII). U.S. Secretary of Commerce Penny Pritzker has announced ... and the Department of Defense has announced the award of a new Advanced ...
(Date:1/18/2017)... IL (PRWEB) , ... January 18, 2017 , ... ... on January 24th, 2017, to sell research and genetic testing lab equipment from ... service in the Northwest and Northeast regions of the United States. This 1-day ...
(Date:1/18/2017)... DIEGO , Jan. 18, 2017  HUYA Bioscience ... of China,s pharmaceutical innovations, announced ... of Sciences Innovation and Investment Company (referred to as ... commercializing biomedical innovations discovered by leading scientists at CAS ... world. HUYA is the first company to ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... (RF) to its VALIDATE® SP2 calibration verification / linearity test kit. VALIDATE® SP2 ... base. Each VALIDATE® SP2 kit is prepared using the CLSI recommended “equal delta” ...
Breaking Biology Technology:
Cached News: