HOME >> BIOLOGY >> NEWS
Researchers find an association between alcohol dependence and the GABAA receptor gene GABRG3

  • Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter in the human central nervous system.
  • Previous research has suggested the involvement of GABAA receptor genes in alcohol use and abuse.
  • New research has found that one GABAA receptor gene in particular, GABRG3, has a consistent association with alcohol dependence.

Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter in the human central nervous system. Previous research has suggested that GABA is involved in many of the neurochemical pathways affecting alcohol use, abuse and dependence. A study in the January issue of Alcoholism: Clinical & Experimental Research, using family-based analyses to examine the role of a cluster of GABAA receptor genes on chromosome 15q, becomes one of the first to demonstrate a consistent association between alcohol dependence and GABAA receptor gene GABRG3.

"There are several lines of evidence that suggest that GABA is involved in alcohol use and abuse," explained Danielle M. Dick, assistant professor in the department of psychiatry at Washington University School of Medicine and first author of the study. "For example, chemicals that increase the activity of GABAA receptors tend to accentuate the behavioral effects of alcohol, such as motor incoordination, sedation, and withdrawal signs, while chemicals that block GABAA receptors lessen these effects."

For this study, Dick and her colleagues decided to focus on GABAA receptor genes on chromosome 15q because of earlier findings from the multi-site Collaborative Study on the Genetics of Alcoholism (COGA) "suggesting a gene influencing alcoholism-related phenotypes in this area," she said.

Tapping into the COGA data once again, researchers tested for an association between alcohol dependence and three chromosome 15q GABAA receptor genes GABRA5, GABRB3, and GABRG3 in 2,282 individuals from 262 alcoholic families.
'"/>


14-Jan-2004


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... Paris Police Prefecture ... solution to ensure the safety of people and operations in ... major tournament Teleste, an international technology group specialised ... today that its video security solution will be utilised by ... public safety across the country. The system roll-out is scheduled ...
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/2/2016)...   The Weather Company , an IBM Business (NYSE: ... capability in which consumers will be able to interact with ... via voice or text and receive relevant information about the ... Marketers have long sought an advertising solution that can create ... relevant and valuable; and can scale across millions of interactions ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... In a ... Hospital in Denmark detail how a patient who developed lymphedema after being treated for ... The results could change the paradigm for dealing with this debilitating, frequent side effect ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... focused on quality, regulatory and technical consulting, provides a free webinar ... presented on July 13, 2016 at 12pm CT at no charge. , Incomplete ...
(Date:6/23/2016)... 23, 2016 ReportsnReports.com adds ... to its pharmaceuticals section with historic and forecast ... much more. Complete report on the ... profiling 15 companies and supported with 261 tables ... . The Global Cell Culture ...
Breaking Biology Technology:
Cached News: